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The cause of cancer mutations: Improvable bad life or inevitable stochastic replication errors?

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Abstract

Despite substantial progress in understanding the mechanisms of carcinogenesis and fighting oncology diseases, cancer mortality remains rather high. Therefore, there is a striving to reduce this mortality to the level determined by endogenous biological factors. The review analyzes the mutations that lead to cell malignant transformation and describes the contribution that self-renewal of adult tissues makes to tumorigenesis. Cancer progression is considered as a development of a complicated system where cells mutate, evolve, and are subject to selection. Cancer paradoxes are described in conclusion.

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Abbreviations

ASC:

adult stem cell

CCO:

cancer cell of origin

BC:

breast cancer

CML:

chronic myeloid leukemia

CIN:

chromosome instability

GIN:

genome instability

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia

    I. V. Alekseenko, A. I. Kuzmich, V. V. Pleshkan, D. V. Tyulkina, M. V. Zinovyeva, M. B. Kostina & E. D. Sverdlov

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  1. I. V. Alekseenko
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  2. A. I. Kuzmich
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  3. V. V. Pleshkan
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  4. D. V. Tyulkina
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  5. M. V. Zinovyeva
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  6. M. B. Kostina
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  7. E. D. Sverdlov
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Correspondence to I. V. Alekseenko.

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Original Russian Text © I.V. Alekseenko, A.I. Kuzmich, V.V. Pleshkan, D.V. Tyulkina, M.V. Zinovyeva, M.B. Kostina, E.D. Sverdlov, 2016, published in Molekulyarnaya Biologiya, 2016, Vol. 50, No. 6, pp. 906–921.

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Alekseenko, I.V., Kuzmich, A.I., Pleshkan, V.V. et al. The cause of cancer mutations: Improvable bad life or inevitable stochastic replication errors?. Mol Biol 50, 799–811 (2016). https://doi.org/10.1134/S0026893316060030

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  • DOI: https://doi.org/10.1134/S0026893316060030

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