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Adult Stem Cels and Their Niches

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The Cell Biology of Stem Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 695))

Abstract

Stem cells participate in dynamic physiologic systems that dictate the outcome of developmental events and organismal stress, Since these cells are fundamental to tissue maintenance and repair, the signals they receive play a critical role in the integrity of the organism. Much work has focused on stem cell identification and the molecular pathways involved in their regulation. Yet, we understand little about how these pathways achieve physiologically responsive stem cell functions. This chapter will review the state of our understanding of stem cells in the context of their microenvironment regarding the relation between stem cell niche dysfunction, carcinogenesis and aging.

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Authors and Affiliations

  1. Harvard Stem Cell Institute, Cambridge, Massachusetts, USA

    Francesca Ferraro & David Scadden

  2. Department of Stem Cell and Regenerative Biology, Harvard University, 185 Cambridge Street, Boston, Massachusetts, USA

    Francesca Ferraro & David Scadden

  3. Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical, Cambridge, Massachusetts, USA

    Francesca Ferraro

  4. Division of Cell and Molecular Biology, Imperial College London, London, England UK

    Cristina Lo Celso

Authors
  1. Francesca Ferraro
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  2. Cristina Lo Celso
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  3. David Scadden
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Correspondence to David Scadden .

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Editors and Affiliations

  1. Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

    Eran Meshorer PhD

  2. Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, California, USA

    Kathrin Plath PhD

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Ferraro, F., Celso, C.L., Scadden, D. (2010). Adult Stem Cels and Their Niches. In: Meshorer, E., Plath, K. (eds) The Cell Biology of Stem Cells. Advances in Experimental Medicine and Biology, vol 695. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7037-4_11

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