Abstract
The optical activity of chitosan has been examined by the optical rotary dispersion method in a wide molecular mass range, beginning from low-molecular analogs of the monomer unit and oligomers. In the spectral range from 300 to 710 nm, all samples demonstrate smooth curves of the optical rotary dispersion. For the polymers and oligomers, these curves lie in the region of negative values of specific optical rotation [α], while for monosaccharides, these curves are in the positive region. High-molecular-mass samples are characterized by maximal −[α] values that are practically independent of molecular mass. For partially depolymerized samples with M < 2 × 105 and for oligomers, the smaller the molecular mass of the sample, the greater the decrease in the modulus of −[α]. The passage to D-glucosamine chlorohydrate and to N-acetyl-D-glucosamine is characterized by inversion of the sign of rotation and achievement of high +[α] values.
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References
Chitin and Chitosan: Synthesis, Properties and Applications, Ed. by K. G. Skryabin, G. A. Vikhoreva, and V. P. Varlamov (Nauka, Moscow, 2002) [in Russian].
Proceedings of VIII International Conference “Horizons in the Investigation of Chitin and Chitosan” (Vseross. Nauchno-Issled. Inst. Rybn. Khoz. Okeanograf., Moscow, 2006).
R. A. A. Muzzarelli, Chitin (Pergamon, Oxford, 1977).
S. N. Kulikov, S. N. Chirkov, A. V. Il’ina, et al., Prikl. Biokhim. Mikrobiol. 42, 224 (2006).
H. K. Holme, A. Hagen, and M. Dornish, in Chitosan Per Os: From Dietary Supplement to Drug Carrier (Atec, Grottammare, 2001), p. 153.
Provisional Pharmacopoeia Clause FSP 42-0314-1478-01, Registration Certificate No. R000913/01-2001.
Yu. M. Evdokimov, V. I. Salyanov, S. V. Semenov, et al., Mol. Biol. (Moscow) 36, 532 (2002).
Yu. M. Evdokimov, Vestn. Ross. Akad. Nauk 73, 712 (2003).
A. B. Shipovskaya, O. F. Kazmicheva, and G. N. Timofeeva, in Structure and Dynamics of Molecular Systems (Inst. Fiz. Mol. Krist., Ufa Nauchn. Tsentr, Ross. Akad. Nauk, Ufa, 2002), Vol. 2, No. IX, p. 293.
V. I. Fomina, N. A. Solonina, O. F. Kazmicheva, et al., in Proceedings of VII International Conference “Horizons in Investigation of Chitin and Chitosan” (Vseross. Nauchno-Issled. Inst. Rybn. Khoz. Okeanograf., Moscow, 2003), p. 367.
A. I. Gamzazade, V. M. Shlimak, A. M. Sklar, et al., Acta Polym., B 36, 420 (1985).
A. M. Sklyar, A. I. Gamzazade, L. Z. Rogovina, et al., Vysokomol. Soedin., Ser. A 23, 1396 (1981).
L. A. Nud’ga, V. A. Petrova, A. M. Bochek, et al., Polymer Science, Ser. B 39, 259 (1997) [Vysokomol. Soedin., Ser. B 39, 1232 (1997)].
Ch. F. Kettering, Newer Methods of Polymer Characterization (Wiley, New York, 1964).
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Original Russian Text © A.B. Shipovskaya, V.I. Fomina, O.F. Kazmicheva, G.N. Timofeeva, B.A. Komarov, 2007, published in Vysokomolekulyarnye Soedineniya, Ser. B, 2007, Vol. 49, No. 12, pp. 2195–2199.
This work was supported by the Russian Foundation for Basic Research (project nos. 03-03-33049a and 06-08-00892a.
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Shipovskaya, A.B., Fomina, V.I., Kazmicheva, O.F. et al. Effect of molecular mass on the optical activity of chitosan. Polym. Sci. Ser. B 49, 288–291 (2007). https://doi.org/10.1134/S156009040711005X
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DOI: https://doi.org/10.1134/S156009040711005X