Skip to main content
Log in

Prevalence of Obstructive Sleep Apnoea in Patients with Metabolic Syndrome: A Prospective Observational Study from a Tertiary Care Centre in North India

  • Original Article
  • Published:
Sleep and Vigilance Aims and scope Submit manuscript

Abstract

Purpose

To find the prevalence of obstructive sleep apnoea (OSA) in patient of metabolic syndrome (MS).

Methods

This is a prospective study conducted in the Department of Pulmonary Medicine at IGMC, Shimla. Total 54 patients (32 males and 22 females) with MS who fulfilled inclusion criteria were enrolled for the study over a period of 1 year. The patients who had symptoms of OSA were subjected to overnight polysomnography.

Results

In this study, total prevalence of OSA was 90.74%. Male and female prevalence were 93.75% and 86.36%, respectively. The prevalence of hypertension was 59.25% and 24.49% of the patients were diabetic. An increased neck circumference (corrected for height) has been suggested as a better sign of obstructive sleep apnoea than other clinical indices. We compared male patient of non-OSA with severe OSA and found significant difference in high-density lipoprotein and triglyceride level.

Conclusion

All patients of metabolic syndrome should be screened for OSA because of sheer high prevalence of this disease. Whether the treatment of OSA can have positive impact on MS patients needs to be further studied in Indian settings.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Younes M. Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders. J Appl Physiol (1985). 2008;105(5):1389–405.

    Article  CAS  Google Scholar 

  2. Levy P, et al. Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives. Eur Respir J. 2008;32(4):1082–95.

    Article  CAS  Google Scholar 

  3. Ryan S, Taylor CT, McNicholas WT. Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation. 2005;112(17):2660–7.

    Article  CAS  Google Scholar 

  4. Lavie L. Oxidative stress inflammation and endothelial dysfunction in obstructive sleep apnea. Front Biosci (Elite Ed). 2012;4:1391–403.

    Article  Google Scholar 

  5. Kumar S, et al. ESAT-6 induced COX-2 expression involves coordinated interplay between PI3K and MAPK signaling. Mol Immunol. 2012;49(4):655–63.

    Article  CAS  Google Scholar 

  6. Sharma SK, et al. Prevalence and risk factors of syndrome Z in urban Indians. Sleep Med. 2010;11(6):562–8.

    Article  Google Scholar 

  7. Misra A, et al. Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. J Assoc Phys India. 2009;57:163–70.

    CAS  Google Scholar 

  8. Wilcox I, et al. “Syndrome Z”: the interaction of sleep apnoea, vascular risk factors and heart disease. Thorax. 1998;53(Suppl 3):S25–8.

    PubMed  PubMed Central  Google Scholar 

  9. Vgontzas AN, Bixler EO, Chrousos GP. Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev. 2005;9(3):211–24.

    Article  Google Scholar 

  10. Agrawal S, et al. Prevalence of metabolic syndrome in a north Indian hospital-based population with obstructive sleep apnoea. Indian J Med Res. 2011;134(5):639–44.

    Article  Google Scholar 

  11. Coughlin SR, et al. Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur Heart J. 2004;25(9):735–41.

    Article  Google Scholar 

  12. Peled N, et al. The association of OSA with insulin resistance, inflammation and metabolic syndrome. Respir Med. 2007;101(8):1696–701.

    Article  Google Scholar 

  13. Bonsignore MR, et al. Metabolic syndrome, insulin resistance and sleepiness in real-life obstructive sleep apnoea. Eur Respir J. 2012;39(5):1136–43.

    Article  CAS  Google Scholar 

  14. Zito A, et al. Obstructive sleep apnoea and metabolic syndrome in Mediterranean countries. Eur Respir J. 2011;37(3):717–9.

    Article  CAS  Google Scholar 

  15. Lam JC, et al. Obstructive sleep apnea and the metabolic syndrome in community-based Chinese adults in Hong Kong. Respir Med. 2006;100(6):980–7.

    Article  Google Scholar 

  16. Drager LF, et al. The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome. PLoS One. 2010;5(8):e12065.

    Article  Google Scholar 

  17. Venkateswaran S, Shankar P. The prevalence of syndrome Z (the interaction of obstructive sleep apnoea with the metabolic syndrome) in a teaching hospital in Singapore. Postgrad Med J. 2007;83(979):329–31.

    Article  Google Scholar 

  18. Millman RP, et al. Daytime hypertension in obstructive sleep apnea. Prevalence and contributing risk factors. Chest. 1991;99(4):861–6.

    Article  CAS  Google Scholar 

  19. Singh A, et al. Polysomnographic study in diabetes mellitus in Central Indian subjects. J Mahatma Gandhi Inst Med Sci. 2012;17:17–21.

    Google Scholar 

  20. Mahmood K, et al. Prevalence of type 2 diabetes in patients with obstructive sleep apnea in a multi-ethnic sample. J Clin Sleep Med. 2009;5(3):215–21.

    PubMed  PubMed Central  Google Scholar 

  21. Meslier N, et al. Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome. Eur Respir J. 2003;22(1):156–60.

    Article  CAS  Google Scholar 

  22. Sasanabe R, et al. Metabolic syndrome in Japanese patients with obstructive sleep apnea syndrome. Hypertens Res. 2006;29(5):315–22.

    Article  Google Scholar 

  23. Davies RJ, Stradling JR. The relationship between neck circumference, radiographic pharyngeal anatomy, and the obstructive sleep apnoea syndrome. Eur Respir J. 1990;3(5):509–14.

    CAS  PubMed  Google Scholar 

  24. Katz I, et al. Do patients with obstructive sleep apnea have thick necks? Am Rev Respir Dis. 1990;141(5 Pt 1):1228–31.

    Article  CAS  Google Scholar 

Download references

Funding

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sunil Sharma.

Ethics declarations

Conflicts of interest

All authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nagpal, P., Sharma, S., Negi, R.S. et al. Prevalence of Obstructive Sleep Apnoea in Patients with Metabolic Syndrome: A Prospective Observational Study from a Tertiary Care Centre in North India. Sleep Vigilance 3, 151–155 (2019). https://doi.org/10.1007/s41782-019-00077-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s41782-019-00077-1

Keywords

Navigation