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Fluorescence Sensing of Inorganic Phosphate and Pyrophosphate Using Small Molecular Sensors and Their Applications

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Abstract

The aim of this contribution is to provide an introduction and a brief summary of the principle of fluorescence molecular sensors specific to inorganic phosphate (Pi) and inorganic pyrophosphate (PPi) as well as their applications. In our introduction we describe the impact of both Pi and PPi in the living organism and in the environment, followed by a description of the principle of fluorescence molecular sensors and the sensing mechanism in solution. We then focus on exciting research which has emerged in recent years on the development of fluorescent sensors specific to Pi and PPi, categorized by chemical interactions between the sensor and the target molecule, such as hydrogen bonding, coordination chemistry, displacement assay, aggregation induced emission or quenching, and chemical reactions.

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Acknowledgements

JW is grateful to the Faculty of Science, Mahidol University and the Thailand Research Fund (IRG5980001).

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Authors and Affiliations

  1. Department of Biotechnology, Faculty of Science, Mahidol University, 272 Rama 6 Road, Bangkok, 10400, Thailand

    Jirarut Wongkongkatep

  2. Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Akio Ojida

  3. Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan

    Itaru Hamachi

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  1. Jirarut Wongkongkatep
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  2. Akio Ojida
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  3. Itaru Hamachi
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Correspondence to Itaru Hamachi.

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This article is part of the Topical Collection “Phosphate Labeling and Sensing in Chemical Biology”; edited by Henning Jessen.

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Wongkongkatep, J., Ojida, A. & Hamachi, I. Fluorescence Sensing of Inorganic Phosphate and Pyrophosphate Using Small Molecular Sensors and Their Applications. Top Curr Chem (Z) 375, 30 (2017). https://doi.org/10.1007/s41061-017-0120-0

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  • DOI: https://doi.org/10.1007/s41061-017-0120-0

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