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Update in Bloodstream Infection Diagnosis Using New Methods in Microbiology

  • New Technologies and Advances in Infection Prevention (AR Marra, Section Editor)
  • Published:
Current Treatment Options in Infectious Diseases Aims and scope Submit manuscript

Opinion statement

Bloodstream infections remain an important cause of morbidity/mortality worldwide. The diagnosis of these infections is time-consuming, even with the use of automated blood culture systems. Several systems based on molecular biology and, more recently, proteomics have been developed to allow rapid and accurate diagnosis of bloodstream infections. Here, we describe some recently technologies and commercial systems available to detect and to identify microorganisms and bacterial antimicrobial resistance-coding genes from positive blood culture bottles and whole-blood samples. Evaluation of clinical outcomes in multicenter studies and clinical trials with these new tests is warranted in conjunction with antimicrobial stewardship use and programs for interpretation of results to be provided to physicians.

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References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Special Clinical Microbiology Laboratory, Infectious Diseases Division, Federal University of São Paulo-UNIFESP, Rua Leandro Dupret, 188, Vila Clementino, São Paulo, SP, 04025-010, Brazil

    Milene Quiles MS, Bruno Boettger BS & Antonio Carlos Campos Pignatari MD, PhD

Authors
  1. Milene Quiles MS
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  2. Bruno Boettger BS
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  3. Antonio Carlos Campos Pignatari MD, PhD
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Corresponding author

Correspondence to Antonio Carlos Campos Pignatari MD, PhD.

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Conflict of Interest

Milene Quiles declares that she has no conflicts of interest.

Bruno Boettger declares that he has no conflicts of interest.

Antonio Carlos Campos Pignatari declares that he has no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Key Points

Rapid and accurate molecular methods are required for diagnosis of BSIs and can contribute for an appropriate antimicrobial therapy institution.

Validation of new molecular methodologies and platforms in the microbiology diagnostic laboratory is essential to evaluate the accuracy and sensibility of these tests before implementation in the clinical routine.

Stewardship programs should be institutionalized for implementation and evaluation of new diagnostic tests in BSIs.

This article is part of the Topical Collection on New Technologies and Advances in Infection Prevention

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Quiles, M., Boettger, B. & Pignatari, A.C.C. Update in Bloodstream Infection Diagnosis Using New Methods in Microbiology. Curr Treat Options Infect Dis 9, 1–10 (2017). https://doi.org/10.1007/s40506-017-0104-1

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  • DOI: https://doi.org/10.1007/s40506-017-0104-1

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