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Engineering Vascularized Composite Tissues by Perfusion Decellularization/Recellularization: Review

  • Cellular Transplants (G Orlando, Section Editor)
  • Published:
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Abstract

Purpose of Review

In the field of tissue engineering, the “perfusion decellularization and recellularization” emerged over the last decade. This technique is generating a complex and perfusable acellular scaffolds (e.g., solid organ) from discarded living tissue. The present work aims to describe all studies in which this technique was applied to complex composite tissues, or one of their elementary tissues.

Recent Findings

A total of 25 experimental publications were found between 2009 and 2020. Studies interested skin/adipose, muscle and nerve flaps for elementary tissues, and larynx, ears, face, upper limbs, uterus, and penis grafts for complex tissue associations. Rat and human models were the most represented.

Summary

This review showed that the current total number of studies covering the entire topic of vascularized composite tissue engineering is only 25, with a majority published within the past 5 years. This promising area of research should be investigated in the future.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Acknowledgements

JD is supported by Fonds de Recherche Clinique (FRC), Cliniques Universitaires Saint-Luc/UCLouvain grant. LM is a “Fonds National de La Recherche Scientifique” (FNRS, Belgium) research fellow

Author information

Authors and Affiliations

  1. Department of Plastic and Reconstructive Surgery, Cliniques Universitaires Saint-Luc, UCLouvain, 10 Avenue Hippocrate, B-1200, Brussels, Belgium

    Jérôme Duisit

  2. Institute for Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium

    Jérôme Duisit & Louis Maistriaux

  3. Department of Plastic, Reconstructive and Aesthetic Surgery, Hospital Sud, University of Rennes 1, Rennes, France

    Nicolas Bertheuil

  4. Department of Plastic Surgery, European George Pompidou Hospital, University of Paris, Paris, France

    Alexandre G. Lellouch

  5. Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, USA

    Alexandre G. Lellouch

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  1. Jérôme Duisit
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  2. Louis Maistriaux
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  3. Nicolas Bertheuil
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  4. Alexandre G. Lellouch
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Correspondence to Jérôme Duisit.

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Duisit, J., Maistriaux, L., Bertheuil, N. et al. Engineering Vascularized Composite Tissues by Perfusion Decellularization/Recellularization: Review. Curr Transpl Rep 8, 44–56 (2021). https://doi.org/10.1007/s40472-021-00317-2

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