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Valsartan Versus Amlodipine Effect on Left Ventricular Multidirectional Deformation and Adipocytokines Levels in Hypertensive Patients: Speckle Tracking Echocardiography

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Abstract

Introduction

Structural and functional properties of the left ventricle (LV) wall have been reported to be altered in hypertension, even at early stages of the disease. Abnormal adipokine levels affect blood pressure regulation. Hypo-adiponectinaemia and hyper-leptinaemia were reported in hypertension.

Aim

To evaluate the effects of valsartan versus amlodipine on LV deformation also, on plasma adiponectin and leptin levels in hypertensive individuals.

Methods

LV strain was measured by two-dimensional speckle tracking echocardiography, plasma levels of adiponectin and leptin was determined in 30 healthy individuals served as control group and in 200 hypertensive patients before and after treatment for 6 months with either valsartan 160 mg or amlodipine 10 mg.

Results

Compared to control group longitudinal strain was significantly affected in hypertensive patients, adiponectin was significantly lower while TNF-α, hs-CRP and leptin levels were significantly higher in hypertensive group. A significant improvement in LV functions, along with a decrease in leptin and increase in adiponectin levels in valsartan group compared to amlodipine group.

Conclusions

Our results indicate that valsartan is superior to amlodipine when it comes to affecting the hormonal function of human adipose tissue. Valsartan has a beneficial effect on LV deformation and function presented in GLS.

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Acknowledgements

Authors thank Damanhour University and Tanta University for supporting our study. Authors also thank medical staff members of Cardiology Department, Tanta University Hospital, Egypt, for their help in collecting patient’s data and samples for analysis.

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Authors and Affiliations

  1. Department of Cardiology, Faculty of Medicine, Tanta University, El-Gharbia, Egypt

    Ibtsam Khairat & Lamiaa Khedr

  2. Department of Clinical Pharmacy, Faculty of Pharmacy, Damanhour University, El-Behaira, 22511, Egypt

    Rehab Werida

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Contributions

IK and LK performed eligibility assessment, participant selection, enrolment, echocardiographic study and collection of clinical data. RW performed statistical analysis of collected data, performed biomarker laboratory investigation of collected samples. All authors shared in literature reviewing, study design construction, wrote and revised the manuscript. All authors read and approved the final manuscript.

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Correspondence to Rehab Werida.

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The authors declares that there is no conflict of interest.

Ethical Approval

The study protocol was approved by Institutional Ethic Committee and was registered in ClinicalTrials.gov with Code No: NCT03990480. All procedures agreed with the Declaration of Helsinki.

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Written informed consent was obtained from all participants.

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Khairat, I., Khedr, L. & Werida, R. Valsartan Versus Amlodipine Effect on Left Ventricular Multidirectional Deformation and Adipocytokines Levels in Hypertensive Patients: Speckle Tracking Echocardiography. High Blood Press Cardiovasc Prev 27, 379–388 (2020). https://doi.org/10.1007/s40292-020-00398-7

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