Abstract
Dimdazenil (Junoenil®) is a small-molecule, oral, partial positive allosteric modulator of the gamma-aminobutyric acid (GABA)A receptor that is being developed by Zhejiang Jingxin Pharmaceutical in collaboration with Evotec for the treatment of insomnia. Dimdazenil is designed to overcome issues associated with full GABAA receptor agonists, such as tolerance, withdrawal symptoms and associated adverse effects. On 29 November 2023, dimdazenil oral capsules received approval in China for the short-term treatment of insomnia. This article summarizes the milestones in the development of dimdazenil leading to this first approval for insomnia.
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References
Edinoff AN, Nix CA, Hollier J, et al. Benzodiazepines: uses, dangers, and clinical considerations. Neurol Int. 2021;13(4):594–607.
Riemann D, Espie CA, Altena E, et al. The European Insomnia Guideline: an update on the diagnosis and treatment of insomnia 2023. J Sleep Res. 2023;32(6): e14035.
Kemp JA, Baur R, Sigel E. EVT 201: a high affinity, partial positive allosteric modulator of GABAA receptors with preference for the α1-subtype [abstract no. 0104]. Sleep. 2008;31(Suppl):A34.
Walsh JK, Thacker S, Knowles LJ, et al. The partial positive allosteric GABAA receptor modulator EVT 201 is efficacious and safe in the treatment of adult primary insomnia patients. Sleep Med. 2009;10(8):859–64.
Wang F, He J, Zhou Y, et al. A phase 1 study of dimdazenil to evaluate the pharmacokinetics, food effect and safety in Chinese healthy subjects. Front Pharmacol. 2023. https://doi.org/10.3389/fphar.2023.1226014.
Zhejiang Jingxin Pharmaceutical. Dimdazenil capsules: Chinese prescribing information. 2023. https://www.cde.org.cn/. Accessed 7 Mar 2024.
National Medical Products Administration. State Food and Drug Administration approves dimdazenil capsules for marketing. 2023. https://www.nmpa.gov.cn/directory/web/nmpa/zhuanti/ypqxgg/gggzjzh/20231129143126185.html. Accessed 7 Mar 2024.
Evotec AG. Evotec licenses phase II insomnia candidate to Jingxin Pharma for development in China [media release] 28 Oct 2010. http://www.evotec.com.
Stanley N, Boyle J, Hunneyball I, et al. A placebo controlled, randomised, double-blind, 4 way cross-over study of 3 doses of EVT201 (2.5 mg, 5 mg and 10 mg) on aspects of sleep and morning after performance using a traffic noise model of sleep disturbance [abstract no. 0750]. Sleep. 2006;29(Suppl):A255.
Boyle J, Stanley N, Hunneyball I, et al. A placebo controlled, randomised, double-blind, 5 way cross-over study of 4 doses of EVT 201 on subjective sleep quality and morning after performance in a traffic noise model of sleep disturbance [abstract no. 0769]. Sleep. 2007;30(Suppl):A262–3.
Stanley N, Wright N, Boyle J, et al. A placebo controlled, randomised, double-blind, 5 way cross-over study of 4 doses of EVT 201 in a traffic noise model of sleep disturbance: PSG and spectral analysis of sleep [abstract no. 0771]. Sleep. 2007;30(Suppl):A263.
Huang Z, Zhan S, Chen C, et al. Efficacy and safety of dimdazenil in adults with insomnia disorder: results from a multicenter, randomized, double-blind, placebo-controlled, phase III trials. Sleep. 2023;47(2):zsad272.
Li Y, Zhang R, Zhou Y, et al. Efficacy and safety of dimdazenil in the adult insomnia patients: a phase II randomized, multicenter, double-blind, placebo-controlled, parallel-group study. Sleep. 2023;47(2):zsad271.
Walsh JK, Salkeld L, Knowles LJ, et al. Treatment of elderly primary insomnia patients with EVT 201 improves sleep initiation, sleep maintenance, and daytime sleepiness. Sleep Med. 2010;11(1):23–30.
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During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Yahiya Y. Syed is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.
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Syed, Y.Y. Dimdazenil: First Approval. Drugs (2024). https://doi.org/10.1007/s40265-024-02020-9
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DOI: https://doi.org/10.1007/s40265-024-02020-9