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Prevention and Treatment of Chronic Postsurgical Pain: A Narrative Review

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Abstract

Chronic postsurgical pain affects between 5 and 75% of patients, often with an adverse impact on quality of life. While the transition of acute to chronic pain is a complex process—involving multiple mechanisms at different levels—the current strategies for prevention have primarily been restricted to perioperative pharmacological interventions. In the present paper, we first present an up-to-date narrative literature review of these interventions. In the second section, we develop several ways by which we could overcome the limitations of the current approaches and enhance the outcome of our surgical patients, including the better identification of individual risk factors, tailoring treatment to individual patients, and improved acute and subacute pain evaluation and management. The third and final section covers the treatment of established CPSP. Given that evidence for the current therapeutic options is limited, we need high-quality trials studying multimodal interventions matched to pain characteristics.

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  1. Department of Anesthesiology, Acute and Transitional Pain Service, Cliniques Universitaires St-Luc, Avenue Hippocrate 10, 1200, Brussels, Belgium

    Arnaud Steyaert & Patricia Lavand’homme

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  1. Arnaud Steyaert
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Correspondence to Arnaud Steyaert.

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Arnaud Steyaert and Patricia Lavand’homme have no conflicts of interest to disclose.

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This research was supported by the Anesthesiology Department of Cliniques Universitaires Saint-Luc.

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Steyaert, A., Lavand’homme, P. Prevention and Treatment of Chronic Postsurgical Pain: A Narrative Review. Drugs 78, 339–354 (2018). https://doi.org/10.1007/s40265-018-0866-x

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