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Treatments for Non-Syndromic Inherited Ichthyosis, Including Emergent Pathogenesis-Related Therapy

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Abstract

The term ‘inherited ichthyosis’ refers to a heterogeneous group of mendelian disorders of cornification that involve the integument with varying degrees of scaling. The management of ichthyosis poses a challenge for most physicians. Treatment options proposed in the literature include moisturizers, topical keratolytics, topical and systemic vitamin D analogues, and topical and systemic retinoids; however, some of these modalities are less reliable than others. Despite the therapeutic impasse imposed by the options above, the emergence of pathogenesis-based treatments along with novel gene therapies appear promising and hold the potential to halt or even revert disorders that arise from single genetic mutations, although research is still quite lacking in this domain. Hence, this review aims to highlight the various treatment modalities available for the management of the cutaneous manifestations of non-syndromic inherited ichthyosis, with an added emphasis on pathogenesis-targeted therapies.

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Authors and Affiliations

  1. Department of Dermatology, American University of Beirut Medical Center, Riad El Solh/Beirut 1107 2020, P.O. Box 11-0236, Beirut, Lebanon

    Divina Justina Hasbani M.D. , Edward Eid M.D., Ossama Abbas M.D. & Mazen Kurban M.D.

  2. Department of Dermatology, Division of Pediatric Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA

    Lamiaa Hamie M.D., MSc.

  3. Department of Radiology, American University of Beirut, Beirut, Lebanon

    Christel Tamer M.D.

  4. Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon

    Mazen Kurban M.D.

  5. Division of Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar

    Mazen Kurban M.D.

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Hasbani, D.J., Hamie, L., Eid, E. et al. Treatments for Non-Syndromic Inherited Ichthyosis, Including Emergent Pathogenesis-Related Therapy. Am J Clin Dermatol 23, 853–867 (2022). https://doi.org/10.1007/s40257-022-00718-8

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