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Pharmacological treatments for cutaneous manifestations of inherited ichthyoses

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Abstract

Inherited ichthyoses are a group of etiologically heterogeneous diseases that affect the function of the skin and that are classified as syndromic and non-syndromic entities. Irrespective of the type, all these disorders are generally produced by mutations in genes involved in a variety of cellular functions in the skin. These mutations lead to disruption of the stratum corneum and impairment of the skin barrier, producing clinical features such as hyperkeratosis, skin scaling, erythema, fissures, pruritus, inflammation, and skin pain. Despite advances in the knowledge of the pathogenesis of ichthyoses, there is, to our knowledge, no definitive cure for skin manifestations, and current treatments consist of moisturizers, emollients, and keratolytic agents. In this respect, the development of new formulations based on nanotechnology could be useful to enhance their therapeutic effectiveness. In this article, we provide a comprehensive description of pharmacological treatments for cutaneous manifestations in patients with inherited ichthyosis and discuss novel approaches with therapeutic potential for this purpose. Moreover, we offer an overview of toxicity concerns related to these treatments.

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Funding

This work was financially supported by a Grant from DGAPA-UNAM to Gerardo Leyva-Gómez (Grant number: PAPIIT TA 200318).

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Authors and Affiliations

  1. Laboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, 14389, Mexico City, Mexico

    Hernán Cortés

  2. Laboratorio de Tecnología Farmacéutica, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Ave. 1o de Mayo S/N, Santa María las Torres, 54740, Cuautitlan Izcalli, Mexico

    María L. Del Prado-Audelo

  3. Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, 04510, Mexico City, Mexico

    María L. Del Prado-Audelo, Zaida Urbán-Morlán & Gerardo Leyva-Gómez

  4. Universidad Autónoma del Estado de Morelos, Facultad de Farmacia, Av. Universidad 1001, Col. Chamilpa, 62209, Cuernavaca, Morelos, Mexico

    Sergio Alcalá-Alcalá

  5. CONACyT-Laboratorio de Biotecnología, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, 14389, Mexico City, Mexico

    Maykel González-Torres

  6. Instituto Tecnológico y de Estudios Superiores de Monterrey, 14380, Mexico City, Mexico

    Maykel González-Torres

  7. Laboratorio de Biología Molecular del Cáncer, UMIEZ, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, 09230, Mexico City, Mexico

    Octavio D. Reyes-Hernández

  8. Facultad de Medicina, Universidad Veracruzana, 94740, Mendoza, Veracruz, Mexico

    Manuel González-Del Carmen

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  1. Hernán Cortés
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  2. María L. Del Prado-Audelo
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Cortés, H., Del Prado-Audelo, M.L., Urbán-Morlán, Z. et al. Pharmacological treatments for cutaneous manifestations of inherited ichthyoses. Arch Dermatol Res 312, 237–248 (2020). https://doi.org/10.1007/s00403-019-01994-x

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