Skip to main content

Advertisement

Log in

Optic Disc Hemorrhages in Glaucoma

  • Diagnosis and Monitoring of Glaucoma (R. Kuchtey, Section Editor)
  • Published:
Current Ophthalmology Reports Aims and scope Submit manuscript

Abstract

Optic disc hemorrhages are a significant clinical sign seen in patients with glaucoma and often herald glaucomatous progression. Longitudinal and population-based studies have shown that disc hemorrhages are most commonly seen in glaucoma, particularly normal tension glaucoma patients. The exact pathophysiology of an optic disc hemorrhage is not completely understood, but both mechanical rupture and vascular dysregulation theories have been proposed. Recent studies using spectral domain optic coherence tomography and visual field progression analysis have highlighted that structural and functional loss both precede and follow detection of an optic disc hemorrhage. The relationship between intraocular pressure and disc hemorrhages is not completely understood as some patients with disc hemorrhages may progress independent of intraocular pressure lowering therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Healey PR, et al. Optic disc hemorrhages in a population with and without signs of glaucoma. Ophthalmology. 1998;105(2):216–23.

    Article  CAS  PubMed  Google Scholar 

  2. Medeiros FA, et al. The relationship between intraocular pressure reduction and rates of progressive visual field loss in eyes with optic disc hemorrhage. Ophthalmology. 2010;117(11):2061–6.

    Article  PubMed  Google Scholar 

  3. Drance S, et al. Risk factors for progression of visual field abnormalities in normal-tension glaucoma. Am J Ophthalmol. 2001;131(6):699–708.

    Article  CAS  PubMed  Google Scholar 

  4. Hollands H, et al. Do findings on routine examination identify patients at risk for primary open-angle glaucoma? The rational clinical examination systematic review. JAMA. 2013;309(19):2035–42.

    Article  CAS  PubMed  Google Scholar 

  5. Sonnsjo B, Dokmo Y, Krakau T. Disc haemorrhages, precursors of open angle glaucoma. Prog Retin Eye Res. 2002;21(1):35–56.

    Article  PubMed  Google Scholar 

  6. Nitta K. Disc hemorrhage is a sign of progression in normal-tension glaucoma. J Glaucoma. 2012;21(4):276.

    PubMed  Google Scholar 

  7. Sung KR. Disc hemorrhage: is that a risk factor or sign of progression? J Glaucoma. 2012;21(4):275–6.

    Article  PubMed  Google Scholar 

  8. Kitazawa Y, Shirato S, Yamamoto T. Optic disc hemorrhage in low-tension glaucoma. Ophthalmology. 1986;93(6):853–7.

    Article  CAS  PubMed  Google Scholar 

  9. Jonas JB, Ritch R. Optic disc haemorrhage and posterior vitreous haemorrhage from an acute posterior vitreous detachment. Clin Exp Ophthalmol. 2012;40(1):e116–7.

    Article  Google Scholar 

  10. Tomidokoro A, et al. Population-based prevalence of optic disc haemorrhages in elderly Japanese. Eye (Lond). 2009;23(5):1032–7.

    Article  CAS  Google Scholar 

  11. Yamamoto T, et al. Optic disc hemorrhages detected in a large-scale eye disease screening project. J Glaucoma. 2004;13(5):356–60.

    Article  PubMed  Google Scholar 

  12. Diehl DL, et al. Prevalence and significance of optic disc hemorrhage in a longitudinal study of glaucoma. Arch Ophthalmol. 1990;108(4):545–50.

    Article  CAS  PubMed  Google Scholar 

  13. Wang Y, et al. Frequency of optic disk hemorrhages in adult chinese in rural and urban china: the Beijing eye study. Am J Ophthalmol. 2006;142(2):241–6.

    Article  PubMed  Google Scholar 

  14. Suh MH, Park KH. Period prevalence and incidence of optic disc haemorrhage in normal tension glaucoma and primary open-angle glaucoma. Clin Exp Ophthalmol. 2011;39(6):513–9.

    Article  Google Scholar 

  15. Bengtsson B, et al. Disc hemorrhages and treatment in the early manifest glaucoma trial. Ophthalmology. 2008;115(11):2044–8.

    Article  PubMed  Google Scholar 

  16. Lan, YW, et al. Characteristics of disc hemorrhage in primary angle-closure glaucoma. Ophthalmology. 2008;115(8):1328–33 1333 e1.

    Article  PubMed  Google Scholar 

  17. Hoyng PF, et al. Platelet aggregation, disc haemorrhage and progressive loss of visual fields in glaucoma. A seven year follow-up study on glaucoma. Int Ophthalmol. 1992;16(2):65–73.

    Article  CAS  PubMed  Google Scholar 

  18. Hsieh JW, et al. Clinical characteristics and prognostic significance of disc hemorrhage in open-angle and angle-closure glaucoma. J Glaucoma. 2010;19(7):483–7.

    Article  PubMed  Google Scholar 

  19. Budenz DL, et al. Detection and prognostic significance of optic disc hemorrhages during the ocular hypertension treatment study. Ophthalmology. 2006;113(12):2137–43.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Budde WM, Mardin CY, Jonas JB. Glaucomatous optic disc hemorrhages on confocal scanning laser tomographic images. J Glaucoma. 2003;12(6):470–4.

    Article  PubMed  Google Scholar 

  21. Kim YK, et al. Topographic characteristics of optic disc hemorrhage in primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2014;55(1):169–76.

    Article  PubMed  Google Scholar 

  22. Ahn JK, Kang JH, Park KH. Correlation between a disc hemorrhage and peripapillary atrophy in glaucoma patients with a unilateral disc hemorrhage. J Glaucoma. 2004;13(1):9–14.

    Article  PubMed  Google Scholar 

  23. Sugiyama K, et al. Disc hemorrhage and peripapillary atrophy in apparently healthy subjects. Acta Ophthalmol Scand. 1999;77(2):139–42.

    Article  CAS  PubMed  Google Scholar 

  24. Jonas JB, et al. Small neuroretinal rim and large parapapillary atrophy as predictive factors for progression of glaucomatous optic neuropathy. Ophthalmology. 2002;109(8):1561–7.

    Article  PubMed  Google Scholar 

  25. Jonas JB, Martus P, Budde WM. Inter-eye differences in chronic open-angle glaucoma patients with unilateral disc hemorrhages. Ophthalmology. 2002;109(11):2078–83.

    Article  PubMed  Google Scholar 

  26. • Furlanetto R.L., et al. Risk factors for optic disc hemorrhage in the low-pressure glaucoma treatment study. Am J Ophthalmol. 2014;157(5):945–52. A study of patients in the Low-Pressure Glaucoma Treatment Study looking at risk factors for an optic disc hemorrhage. Frequency of disc hemorrhages did not differ between treatment groups (timolol 0.5 % or brimonidine 0.2 %).

  27. Schor KS, et al. Rates of visual field progression in distinct optic disc phenotypes. Clin Exp Ophthalmol. 2012;40(7):706–12.

    Article  Google Scholar 

  28. Quigley HA. Reappraisal of the mechanisms of glaucomatous optic nerve damage. Eye (Lond). 1987;1(Pt 2):318–22.

    Article  Google Scholar 

  29. Bojikian KD, et al. Optic disc hemorrhage after phacoemulsification in patients with glaucoma. ISRN Ophthalmol. 2014;2014:574054.

    Article  PubMed Central  PubMed  Google Scholar 

  30. Chen BH, et al. Progression of normal-tension glaucoma after ventriculoperitoneal shunt to decrease cerebrospinal fluid pressure. J Glaucoma. 2014. doi:10.1097/IJG.0000000000000186.

    Google Scholar 

  31. • Lee E.J., et al. Recent structural alteration of the peripheral lamina cribrosa near the location of disc hemorrhage in glaucoma. Invest Ophthalmol Vis Sci. 2014;55(4):2805–15. Enhanced depth imaging optical coherence tomography showing recent structural changes in the lamina cribrosa occurred more frequently in eyes with a disc hemorrhage.

  32. Faridi OS, et al. Effect of focal lamina cribrosa defect on glaucomatous visual field progression. Ophthalmology. 2014;121(8):1524–30.

    Article  PubMed  Google Scholar 

  33. Chung E, et al. Structural glaucomatous progression before and after occurrence of an optic disc haemorrhage. Br J Ophthalmol. 2015;99(1):21–5.

    Article  PubMed  Google Scholar 

  34. Park HY, Jeon SH, Park CK. Enhanced depth imaging detects lamina cribrosa thickness differences in normal tension glaucoma and primary open-angle glaucoma. Ophthalmology. 2012;119(1):10–20.

    Article  PubMed  Google Scholar 

  35. Choi YJ, et al. Microstructure of the optic disc pit in open-angle glaucoma. Ophthalmology. 2014;121(11):2098–106 e2.

    Article  PubMed  Google Scholar 

  36. Park SC, et al. Factors associated with focal lamina cribrosa defects in glaucoma. Invest Ophthalmol Vis Sci. 2013;54(13):8401–7.

    Article  PubMed  Google Scholar 

  37. Grodum K, Heijl A, Bengtsson B. Optic disc hemorrhages and generalized vascular disease. J Glaucoma. 2002;11(3):226–30.

    Article  PubMed  Google Scholar 

  38. Soares AS, et al. Factors associated with optic disc hemorrhages in glaucoma. Ophthalmology. 2004;111(9):1653–7.

    Article  PubMed  Google Scholar 

  39. Kim YD, et al. Risk factors associated with optic disc haemorrhage in patients with normal tension glaucoma. Eye (Lond). 2010;24(4):567–72.

    Article  Google Scholar 

  40. Kim SJ, Park KH. Four cases of normal-tension glaucoma with disk hemorrhage combined with branch retinal vein occlusion in the contralateral eye. Am J Ophthalmol. 2004;137(2):357–9.

    Article  PubMed  Google Scholar 

  41. Yoo YC, Park KH. Disc hemorrhages in patients with both normal tension glaucoma and branch retinal vein occlusion in different eyes. Korean J Ophthalmol. 2007;21(4):222–7.

    Article  PubMed Central  PubMed  Google Scholar 

  42. Grieshaber MC, Terhorst T, Flammer J. The pathogenesis of optic disc splinter haemorrhages: a new hypothesis. Acta Ophthalmol Scand. 2006;84(1):62–8.

    Article  PubMed  Google Scholar 

  43. Jonas JB, Budde WM, Panda-Jonas S. Ophthalmoscopic evaluation of the optic nerve head. Surv Ophthalmol. 1999;43(4):293–320.

    Article  CAS  PubMed  Google Scholar 

  44. Kurvinen L, et al. Altered temporal peripapillary retinal flow in patients with disc hemorrhages. Graefes Arch Clin Exp Ophthalmol. 2010;248(12):1771–5.

    Article  PubMed  Google Scholar 

  45. • Kernstock C., et al. Optical coherence tomography shows progressive local nerve fiber loss after disc hemorrhages in glaucoma patients. Graefes Arch Clin Exp Ophthalmol. 2012;250(4):583–7. Study using optical coherence tomography to show nerve fiber layer defects in eyes with disc hemorrhages.

  46. Nitta K, et al. Does the enlargement of retinal nerve fiber layer defects relate to disc hemorrhage or progressive visual field loss in normal-tension glaucoma? J Glaucoma. 2011;20(3):189–95.

    Article  PubMed  Google Scholar 

  47. Kim HS, et al. Comparison of myopic and nonmyopic disc hemorrhage in primary open-angle glaucoma. Jpn J Ophthalmol. 2013;57(2):166–71.

    Article  PubMed  Google Scholar 

  48. Liou SY, et al. Morphometric characteristics of optic disk with disk hemorrhage in normal-tension glaucoma. Am J Ophthalmol. 2001;132(5):618–25.

    Article  CAS  PubMed  Google Scholar 

  49. Sugiyama K, et al. The associations of optic disc hemorrhage with retinal nerve fiber layer defect and peripapillary atrophy in normal-tension glaucoma. Ophthalmology. 1997;104(11):1926–33.

    Article  CAS  PubMed  Google Scholar 

  50. Ikram MK, et al. Comparing ophthalmoscopy, slide viewing, and semiautomated systems in optic disc morphometry. Ophthalmology. 2002;109(3):486–93.

    Article  PubMed  Google Scholar 

  51. Sugiyama K, et al. Localized wedge-shaped defects of retinal nerve fiber layer and disc hemorrhage in glaucoma. Ophthalmology. 1999;106(9):1762–7.

    Article  CAS  PubMed  Google Scholar 

  52. Boehm MD, et al. Scanning laser polarimetry and detection of progression after optic disc hemorrhage in patients with glaucoma. Arch Ophthalmol. 2003;121(2):189–94.

    Article  PubMed  Google Scholar 

  53. Gunvant P, et al. Predicting subsequent visual field loss in glaucomatous subjects with disc hemorrhage using retinal nerve fiber layer polarimetry. J Glaucoma. 2005;14(1):20–5.

    Article  PubMed  Google Scholar 

  54. Lee EJ, et al. Ability of Stratus OCT to detect progressive retinal nerve fiber layer atrophy in glaucoma. Invest Ophthalmol Vis Sci. 2009;50(2):662–8.

    Article  PubMed  Google Scholar 

  55. •• Wollstein G., et al., Retinal nerve fibre layer and visual function loss in glaucoma: the tipping point. Br J Ophthalmol, 2012;96(1):47–52. Structurefunction relationship study showing that a threshold of nerve fiber layer loss of 17.3 % was necessary prior to detection of visual field loss.

  56. Law SK, Choe R, Caprioli J. Optic disk characteristics before the occurrence of disk hemorrhage in glaucoma patients. Am J Ophthalmol. 2001;132(3):411–3.

    Article  CAS  PubMed  Google Scholar 

  57. Radcliffe NM, et al. Anatomic relationships between disc hemorrhage and parapapillary atrophy. Am J Ophthalmol. 2008;146(5):735–40.

    Article  PubMed  Google Scholar 

  58. Jeoung JW, et al. Optic disc hemorrhage may be associated with retinal nerve fiber loss in otherwise normal eyes. Ophthalmology. 2008;115(12):2132–40.

    Article  PubMed  Google Scholar 

  59. Ahn JK, Park KH. Morphometric change analysis of the optic nerve head in unilateral disk hemorrhage cases. Am J Ophthalmol. 2002;134(6):920–2.

    Article  PubMed  Google Scholar 

  60. Hwang YH, et al. Changes in retinal nerve fiber layer thickness after optic disc hemorrhage in glaucomatous eyes. J Glaucoma. 2014;23(8):547–52.

    Article  PubMed  Google Scholar 

  61. • Suh M.H., et al., Glaucoma progression after the first-detected optic disc hemorrhage by optical coherence tomography. J Glaucoma, 2012;21(6):358–66. Optical coherence tomography study showing glaucomatous anatomic progression in the location of a previous optic disc hemorrhage.

  62. Gracitelli CP, et al. Estimated rates of retinal ganglion cell loss in glaucomatous eyes with and without optic disc hemorrhages. PLoS ONE. 2014;9(8):e105611.

    Article  PubMed Central  PubMed  Google Scholar 

  63. •• Ernest P.J., et al., An evidence-based review of prognostic factors for glaucomatous visual field progression. Ophthalmology. 2013;20(3):512–9. A review of 85 articles looking at prognostic factors for visual field progression. Disc hemorrhages were found to be associated with visual field progression in NTG.

  64. Anderson DR, et al. Factors that predict the benefit of lowering intraocular pressure in normal tension glaucoma. Am J Ophthalmol. 2003;136(5):820–9.

    Article  PubMed  Google Scholar 

  65. Tezel G, et al. Clinical factors associated with progression of glaucomatous optic disc damage in treated patients. Arch Ophthalmol. 2001;119(6):813–8.

    Article  CAS  PubMed  Google Scholar 

  66. Kim KE, et al. Long-term follow-up in preperimetric open-angle glaucoma: progression rates and associated factors. Am J Ophthalmol. 2015;159(1):160–8 e2.

    Article  PubMed  Google Scholar 

  67. • De Moraes C.G., et al., Rate of visual field progression in eyes with optic disc hemorrhages in the ocular hypertension treatment study. Arch Ophthalmol. 2012;130(12):1541–6. A study comparing visual field progression in eyes from the Ocular Hypertension Treatment Study with and without disc hemorrhages. Ocular hypertensive eyes with disc hemorrhages were found to have more rapid visual field decline.

  68. Hendrickx KH, et al. Cumulative incidence of patients with disc hemorrhages in glaucoma and the effect of therapy. Ophthalmology. 1994;101(7):1165–72.

    Article  CAS  PubMed  Google Scholar 

  69. Miyake T, et al. Incidence of disc hemorrhages in open-angle glaucoma before and after trabeculectomy. J Glaucoma. 2006;15(2):164–71.

    Article  PubMed  Google Scholar 

  70. Park SC, et al. Initial parafoveal versus peripheral scotomas in glaucoma: risk factors and visual field characteristics. Ophthalmology. 2011;118(9):1782–9.

    Article  PubMed  Google Scholar 

  71. Rao A, Mukherjee S. Anatomical attributes of the optic nerve head in eyes with parafoveal scotoma in normal tension glaucoma. PLoS ONE. 2014;9(3):e90554.

    Article  PubMed Central  PubMed  Google Scholar 

  72. Drance S. Chronic open angle glaucoma: risk factors in addition to intraocular pressure. Acta Ophthalmol Scand. 2001;79(6):545.

    Article  CAS  PubMed  Google Scholar 

  73. Gordon J, Piltz-Seymour JR. The significance of optic disc hemorrhages in glaucoma. J Glaucoma. 1997;6(1):62–4.

    Article  CAS  PubMed  Google Scholar 

  74. Keltner JL, et al. The association between glaucomatous visual fields and optic nerve head features in the ocular hypertension treatment study. Ophthalmology. 2006;113(9):1603–12.

    Article  PubMed  Google Scholar 

  75. Wang YX, et al. Frequency and associated factors of structural progression of open-angle glaucoma in the Beijing eye study. Br J Ophthalmol. 2012;96(6):811–5.

    Article  PubMed  Google Scholar 

  76. Xu L, et al. Follow-up of glaucomatous eyes with optic disc haemorrhages: the Beijing eye study. Acta Ophthalmol. 2009;87(2):235.

    Article  PubMed  Google Scholar 

  77. Ishida K, et al. Disk hemorrhage is a significantly negative prognostic factor in normal-tension glaucoma. Am J Ophthalmol. 2000;129(6):707–14.

    Article  CAS  PubMed  Google Scholar 

  78. Kono Y, et al. Characteristics of visual field progression in patients with normal-tension glaucoma with optic disk hemorrhages. Am J Ophthalmol. 2003;135(4):499–503.

    Article  PubMed  Google Scholar 

  79. De Moraes CG, et al. Risk factors for visual field progression in treated glaucoma. Arch Ophthalmol. 2011;129(5):562–8.

    Article  PubMed  Google Scholar 

  80. Daugeliene L, Yamamoto T, Kitazawa Y. Risk factors for visual field damage progression in normal-tension glaucoma eyes. Graefes Arch Clin Exp Ophthalmol. 1999;237(2):105–8.

    Article  CAS  PubMed  Google Scholar 

  81. Kim M, et al. Intraocular pressure reduction with topical medications and progression of normal-tension glaucoma: a 12-year mean follow-up study. Acta Ophthalmol. 2013;91(4):e270–5.

    Article  PubMed  Google Scholar 

  82. Komori S, Ishida K, Yamamoto T. Results of long-term monitoring of normal-tension glaucoma patients receiving medical therapy: results of an 18-year follow-up. Graefes Arch Clin Exp Ophthalmol. 2014;252(12):1963–70.

    Article  CAS  PubMed  Google Scholar 

  83. Rasker MT, et al. Deterioration of visual fields in patients with glaucoma with and without optic disc hemorrhages. Arch Ophthalmol. 1997;115(10):1257–62.

    Article  CAS  PubMed  Google Scholar 

  84. De Moraes CG, et al. Spatially consistent, localized visual field loss before and after disc hemorrhage. Invest Ophthalmol Vis Sci. 2009;50(10):4727–33.

    Article  PubMed  Google Scholar 

  85. Prata TS, et al. Factors affecting rates of visual field progression in glaucoma patients with optic disc hemorrhage. Ophthalmology. 2010;117(1):24–9.

    Article  PubMed  Google Scholar 

  86. Hsieh JW, Lan YW. Progression of optic neuropathy after disc hemorrhage in primary angle-closure glaucoma. Jpn J Ophthalmol. 2009;53(4):380–3.

    Article  PubMed  Google Scholar 

  87. de Beaufort HC, et al. Recurrent disc hemorrhage does not increase the rate of visual field progression. Graefes Arch Clin Exp Ophthalmol. 2010;248(6):839–44.

    Article  PubMed  Google Scholar 

  88. Kim SH, Park KH. The relationship between recurrent optic disc hemorrhage and glaucoma progression. Ophthalmology. 2006;113(4):598–602.

    Article  PubMed  Google Scholar 

  89. Choi F, et al. Retinal nerve fiber layer thickness evaluation using optical coherence tomography in eyes with optic disc hemorrhage. Ophthalmic Surg Lasers Imaging. 2007;38(2):118–25.

    PubMed  Google Scholar 

  90. Araie M, et al. Risk factors for progression of normal-tension glaucoma under beta-blocker monotherapy. Acta Ophthalmol. 2012;90(5):e337–43.

    Article  PubMed  Google Scholar 

  91. Jonas JB, et al. Central corneal thickness and development of glaucomatous optic disk hemorrhages. Am J Ophthalmol. 2005;140(6):1139–41.

    Article  PubMed  Google Scholar 

  92. Xu L, et al. Central corneal thickness and glaucoma in adult Chinese: the Beijing eye study. J Glaucoma. 2008;17(8):647–53.

    Article  PubMed  Google Scholar 

  93. Park HY, et al. Nail bed hemorrhage: a clinical marker of optic disc hemorrhage in patients with glaucoma. Arch Ophthalmol. 2011;129(10):1299–304.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

Supported in part by an unrestricted departmental grant from Research to Prevent Blindness, Inc., New York, NY.

Disclosure

Dr. Gupta and Dr. Chen both declare they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article contains no studies with human or animal subjects performed by any of the authors.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Divakar Gupta.

Additional information

This article is part of the Topical Collection on Diagnosis and Monitoring of Glaucoma.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gupta, D., Chen, P.P. Optic Disc Hemorrhages in Glaucoma. Curr Ophthalmol Rep 3, 91–97 (2015). https://doi.org/10.1007/s40135-015-0064-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40135-015-0064-x

Keywords

Navigation