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Burden of Candida-related vascular graft infection: a nested-case control study

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Abstract

Purpose

We aimed to assess risk factors of candida-related Vascular Graft Infections (VGIs).

Methods

We did a case–control study (1:4) matched by age and year of infection, nested in a cohort of patient with a history of VGIs. Cases were defined by a positive culture for Candida spp. in biological samples and controls were defined by a positive culture for bacterial strains only in biological samples. Risk factors for Candida-related VGIs were investigated using multivariate logistic regression. Mortality were compared using survival analysis.

Results

16 Candida-related VGIs were matched to 64 bacterial-related VGIs. The two groups were comparable regarding medical history and clinical presentation. Candida-related VGIs were associated with bacterial strains in 88% (14/16). Gas/fluid-containing collection on abdominal CT scan and the presence of an aortic endoprosthesis were risk factors for Candida spp.-related VGIs [RRa 10.43 [1.81–60.21] p = 0.009 RRa and 6.46 [1.17–35.73] p = 0.03, respectively]. Candida-related VGIs were associated with a higher mortality when compared to bacterial-related VGIs (p = 0.002).

Conclusions

Candida-related VGIs are severe. Early markers of Candida spp. infection are needed to improve their outcome. The suspicion of aortic endoprosthesis infection may necessitate probabilistic treatment with antifungal agents.

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Data availability

The data is available from the authors (OR) upon reasonable request.

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Acknowledgments

The authors thank Hospital of Tourcoing’s data manager for their valuable contribution.

Funding

No funding was received to assist with the preparation of this manuscript.

Author information

Authors and Affiliations

  1. Service de Réanimation, CH de Tourcoing, France

    Thomas Caulier, Olivier Leroy, Hugues Georges & Delannoy Pierre-Yves

  2. Service Universitaire Des Maladies Infectieuses Et du Voyageur, Centre Hospitalier Gustave Dron, 59210, Tourcoing, France

    Eric Senneville & Olivier Robineau

  3. University of Lille, CHU Lille, ULR 2694, METRICS, Évaluation Des Technologies de Santé Et Des Pratiques Médicales, 59000, Lille, France

    Eric Senneville & Olivier Robineau

  4. Service de Chirurgie Vasculaire, CHRU de Lille, Lille, France

    Jonathan Sobocinski

  5. Service de Biologie, CH de Tourcoing, France

    Pierre Patoz & Nicolas Blondiaux

  6. University of Lille, CNRS, Inserm, Institut Pasteur de Lille, U1019, UMR9017 Center for Infection and Immunity of Lille, Lille, France

    Nicolas Blondiaux

  7. Service de Chirurgie Vasculaire, CH de Tourcoing, France

    PierVito d’Elia

  8. INSERM u1136, Institut Pierre Louis de Santé Publique, Paris, France

    Olivier Robineau

Authors
  1. Thomas Caulier
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  2. Eric Senneville
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  3. Jonathan Sobocinski
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  4. Olivier Leroy
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  7. Hugues Georges
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  8. Delannoy Pierre-Yves
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  10. Olivier Robineau
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Contributions

T.C., O.R., E.S. wrote the protocole T.C., J.S., O.L.,P.D., O.R., N.B., P.P. and E.S. collected the data O.R. did the statistical analysis. T.C., O.R., E.S. wrote the main manuscript. All authors reviewed the manuscript.

Corresponding author

Correspondence to Olivier Robineau.

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Competing interests

The authors declare no competing interests.

Conflict of interest

OR reports personal fees and non-financial support from ViiV healthcare, Gilead, MSD, not related to this work.

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Caulier, T., Senneville, E., Sobocinski, J. et al. Burden of Candida-related vascular graft infection: a nested-case control study. Infection (2024). https://doi.org/10.1007/s15010-023-02172-y

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