Abstract
Purpose of Review
This review analyzes the presentation, manifestations, and management decisions for elderly patients with infectious endocarditis (IE).
Recent Findings
There are significant differences in IE across ages. Whereas the major risk factors for younger individuals include intravenous drug use and complex congenital heart disease, older adults tend to develop IE on prosthetic valves or in the setting of degenerative valve disease. Nosocomial disease is important regardless of age. The microbiology differs too for elderly patients. Although Staphylococcus aureus is universally an important pathogen, elderly patients are more likely to have IE from S. gallolyticus and Enterococci. New tools for risk stratification may better estimate true surgical risk for elderly patients with IE.
Summary
The epidemiology of IE has shifted over the last several decades, making it increasingly a disease of the elderly, who tend to have worse outcomes. It is important to understand how IE manifests in elderly patients in order to manage it appropriately.
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References
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Karchmer AW. Infective endocarditis. In: Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison’s Principles of Internal Medicine 19th Edition. McGraw Hill Education; 2015.
Holland TL, Baddour LM, Bayer AS, Hoen B, Miro JM, Fowler VG. Infective endocarditis. Nat Rev Dis Primers. 2017;2:16059. https://doi.org/10.1038/nrdp.2016.59.
Veloso TR, Chaouch A, Roger T, Giddey M, Vouillamoz J, Majcherczyk P, et al. Use of a human-like low-grade bacteremia model of experimental endocarditis to study the role of Staphylococcus aureus adhesins and platelet aggregation in early endocarditis. Infect Immun. 2013;81:697–703. https://doi.org/10.1128/IAI.01030-12.
Silver B, Behrouz R, Silliman S. Bacterial endocarditis and cerebrovascular disease. Curr Neurol Neurosci Rep. 2016;16:104. https://doi.org/10.1007/s11910-016-0705-y.
Hoen B, Duval X. Clinical practice: infective endocarditis. N Engl J Med. 2013;368:1425–33. https://doi.org/10.1056/NEJMcp1206782.
•• Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, et al. ESC Guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European Society of Cardiology. Eur Heart J. 2015;36:3075–128. https://doi.org/10.1093/eurheartj/ehv319. This article contains the most recent guidelines and their evidence for diagnosis and management of infectious endocarditis.
Coffey S, Cairns BJ, Iung B. The modern epidemiology of heart valve disease. Heart. 2016;102:75–85. https://doi.org/10.1136/heartjnl-2014-307020.
Vogkou CT, Vlachogiannis NI, Palaiodimos L, Kousoulis AA. The causative agents in infective endocarditis: a systematic review comprising 33,214 cases. Eur J Clin Microbiol Infect Dis. 2016;35:1227–45. https://doi.org/10.1007/s10096-016-2660-6.
Toyoda N, Chikwe J, Itagaki S, Gelijns AC, Adams DH, Egorova NN. Trends in infective endocarditis in California and New York State, 1998-2013. JAMA. 2017;317:1652–60. https://doi.org/10.1001/jama.2017.4287.
Forestier E, Fraisse T, Roubaud-Baudron C, Selton-Suty C, Pagani L. Managing infective endocarditis in the elderly: new issues for an old disease. Clin Interv Aging. 2016;11:1199–206. https://doi.org/10.2147/CIA.S101902.
Lopez-Wolf D, Vilacosta I, San Roman JA, Fernandez C, Sarria C, Lopez J, et al. Infective endocarditis in octogenarian patients. Rev Esp Cardiol. 2011;64:329–33. https://doi.org/10.1016/j.rec.2010.05.005.
• Oliver L, Lavoute C, Giorgi R, Salaun E, Hubert S, Casalta JP, et al. Infective endocarditis in octogenarians. Heart. 2017;0:1–8. https://doi.org/10.1136/heartjnl-2016-310853. This recent and particularly well done prospective cohort study analyzes the different features of infectious endocarditis in elderly compared to younger patients.
Tada A, Hanada N. Opportunistic respiratory pathogens in the oral cavity of the elderly. FEMS Immunol Med Microbiol. 2010;60:1–17. https://doi.org/10.1111/j.1574-695X.2010.00709.
Selton-Suty C, Hoen B, Grentzinger A, Houplon P, Maignan M, Juilliere Y, et al. Clinical and bacteriological characteristics of infective endocarditis in the elderly. Heart. 1997;77:260–3. https://doi.org/10.1136/hrt.77.3.260.
Chirillo F. It is not how old you are, it is how you are old: need for changes in the management of infective endocarditis in the elderly. Heart. 2017;0:1–3. https://doi.org/10.1136/heartjnl-2017-311411.
Cone LA, Hirschberg J, Lopez C, Kanna PK, Goldstein EJC, Kazi A, et al. Infective endocardtitis associated with spondylodiscitis and frequent secondary epidural abscess. Surg Neurol. 2008;69:121–5. https://doi.org/10.1016/j.surneu.2007.03.024.
Thomas P, Allal J, Bontoux D, Rossi F, Poupet JY, Petitalot P, et al. Rheumatological manifestations of infective endocarditis. Ann Rheum Dis. 1984;43:716–20. https://doi.org/10.1136/ard.43.5.716.
Kang DH. Timing of surgery in infective endocarditis. Heart. 2015;101:1786–91. https://doi.org/10.1136/heartjnl-2015-307878.
• Olmos C, Vilacosta I, Habib G, Maroto L, Fernandez C, Lopez J, et al. Risk score for cardiac surgery in active left-sided infective endocarditis. Heart. 2017;103:1435–42. https://doi.org/10.1136/heartjnl-2016-311093. This fascinating and thorough article proposes a new risk score to determine cardiac risk for patients with left-sided IE. Of note it more accurately estimates risk for older patients who may have their surgical risk overestimated by other risk calculators.
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This article is part of the Topical Collection on Cardiovascular Disease in the Elderly
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Meyerowitz, E.A., Dhanireddy, S. Care of the Elderly Patient with Infective Endocarditis. Curr Geri Rep 6, 290–296 (2017). https://doi.org/10.1007/s13670-017-0229-6
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DOI: https://doi.org/10.1007/s13670-017-0229-6