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Piezo protein determines stem cell fate by transmitting mechanical signals

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Abstract

Piezo ion channel is a mechanosensitive protein on the cell membrane, which contains Piezo1 and Piezo2. Piezo channels are activated by mechanical forces, including stretch, matrix stiffness, static pressure, and shear stress. Piezo channels transmit mechanical signals that cause different downstream responses in the differentiation process, including integrin signaling pathway, ERK1/2 MAPK signaling pathway, Notch signaling, and WNT signaling pathway. In the fate of stem cell differentiation, scientists found differences in Piezo channel expression and found that Piezo channel expression is related to developmental diseases. Here, we briefly review the structure and function of Piezo channels and the relationship between Piezo and mechanical signals, discussing the current understanding of the role of Piezo channels in stem cell fate and associated molecules and developmental diseases. Ultimately, we believe this review will help identify the association between Piezo channels and stem cell fate.

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The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

This study was funded by Science and Technology Projects of the Education Department of Jilin Province (Grant No. JJKH20211154KJ). The authors confirm independence from the sponsors; the content of the article has not been influenced by the sponsors.

Funding

This study was funded by the National Natural Science Foundation of China (Grant No. 31201052) and the Project of the Science and Technology Department of Jilin Province (Grant No. 20210509003RQ). The authors confirm independence from the sponsors; the content of the article has not been influenced by the sponsors.

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  1. Xiaolei Qiu, Zhuoyue Deng and Meijing Wang have contributed equally to this work.

Authors and Affiliations

  1. Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, China

    Xiaolei Qiu

  2. The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China

    Xiaolei Qiu, Zhuoyue Deng, Yuqi Feng & Lisha Li

  3. Department of Hematology and Oncology, China-Japan Union Hospital of Jilin University, Changchun, 130033, China

    Lintao Bi

  4. Department of Pathology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710004, China

    Meijing Wang

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XQ, ZD, MW, and YF participated in the writing. XQ, ZD, and MW designed and prepared the figures and tables. YF was in charge of proofreading manuscripts. LL and LB designed and polished the paper.

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Qiu, X., Deng, Z., Wang, M. et al. Piezo protein determines stem cell fate by transmitting mechanical signals. Human Cell 36, 540–553 (2023). https://doi.org/10.1007/s13577-022-00853-8

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