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Cardiovascular autonomic neuropathy and charcot neuroarthropathy in type 2 diabetes: adding a new severity classification score

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Objective

This study aimed to assess the presence and characteristics of cardiovascular autonomic neuropathy (CAN) in people with type 2 diabetes with and without Charcot neuroarthropathy (CN).

Background

Diabetes can affect nerves in many ways beyond sensitive neuropathy.

Methods

A cross-sectional study was carried out in people with diabetes and CN who were matched for sex and age with two groups of people with diabetes without CN. All subjects underwent CAN assessment with seven tests (four Ewing tests and three bands of spectral analysis), and a severity score was constructed using these seven tests (each altered test equivalent to 1 point).

Results

Of the 69 people evaluated, 49 (71%) had incipient or installed CAN. A total of 95.2% of people with Charcot neuroarthropathy had incipient or installed CAN. There was a higher prevalence of dyslipidemia among people with installed autonomic neuropathy than among those with incipient CAN or without CAN. Thirty-four (69%) people with CAN had increased urinary albumin excretion. The severity score, constructed from the seven tests used for the diagnosis of CAN, revealed a greater number of altered tests and higher scores among people with CN when compared to the other participants, indicating greater severity of the condition.

Conclusions

There is a high prevalence of CAN in people with type 2 diabetes followed in a tertiary health service and the use of severity score may enable to differentiate people with or without CN. We suggest that this score could be used as a new tool in caring for people with diabetes to identify the most severe CAN.

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Data availability

The entire data supporting the results of this study was published in the article itself.

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Funding

This supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (303068/2021–3) through Denise Engelbrecht Zantut-Wittmann.

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Authors and Affiliations

  1. Endocrinology Division, Department of Internal Medicine (Endocrinology), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

    Jessica Castro de Vasconcelos, Yeelen Ballesteros Atala, Denise Engelbrecht Zantut-Wittmann & Maria Cândida Ribeiro Parisi

Authors
  1. Jessica Castro de Vasconcelos
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  2. Yeelen Ballesteros Atala
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  3. Denise Engelbrecht Zantut-Wittmann
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  4. Maria Cândida Ribeiro Parisi
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Jessica Castro de Vasconcelos, Yeelen Ballesteros Atala, Denise Engelbrecht Zantut-Wittmann, and Maria Cândida Ribeiro Parisi. The first draft of the manuscript was written by Jessica Castro de Vasconcelos, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Jessica Castro de Vasconcelos.

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Ethical clearance and consent of patient

This study was approved by the ethical and research committee of University of Campinas, São Paulo, Brazil. All patients filled out a consent form stating that they agreed to participate in the study.

Competing interests

The authors declare no competing interests.

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de Vasconcelos, J.C., Atala, Y.B., Zantut-Wittmann, D.E. et al. Cardiovascular autonomic neuropathy and charcot neuroarthropathy in type 2 diabetes: adding a new severity classification score. Int J Diabetes Dev Ctries (2024). https://doi.org/10.1007/s13410-024-01328-2

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