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Correlation between insulin resistance score and daily total insulin dosage in patient with type 1 diabetes mellitus: a pilot study

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Abstract

Purpose of the study

Although insulin resistance is the pathogenic basis of type 2 diabetes mellitus (T2DM), it can also affect patients with type 1 diabetes mellitus (T1DM). In this clinical study, we investigated the relationship between insulin resistance grade and daily insulin dosage in order to clarify whether the approach to improving insulin resistance along with insulin therapy should be considered to treat T1DM and T2DM.

Methods

As the means of insulin resistance estimation, we selected the insulin resistance score because patients use insulin therapy and homeostatic model assessment insulin resistance (HOMA-IR) is not appropriate for those patients. The insulin resistance score was calculated as 24.31 – (12.22 × WHR) – (3.29 × HT) – (0.57 × HbA1c), where WHR is the waist-to-hip ratio, HT is hypertension, and HbA1c is glycated hemoglobin (%).

Results

The insulin resistance score was negatively correlated with the body mass index (BMI; r = –0.511) and the WHR (r = –0.773). The total insulin dosage was positively correlated with the BMI (r = 0.734) but negatively correlated with the insulin resistance score (r = –0.540).

Conclusion

Insulin resistance estimation is necessary for T1DM treatment, and the insulin resistance score is a useful tool for estimating insulin resistance in patients with T1DM accompanied with insulin resistance.

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Data availability

The datasets generated or analyzed during the current study are available from the corresponding author on reasonable request.

Code availability

Not applicable.

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Acknowledgments

The manuscript was edited by MARUZEN Editing service.

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Authors and Affiliations

  1. Hidaka Hospital, 886 Nakao-machi, Takasaki, Gunma, 370-0001, Japan

    Shuichi Okada, Koji Kikkawa & Kihachi Ohsima

  2. Department of Endocrinology and Metabolism, Saku Central Hospital Advanced Care Center, 28-3400 Nakagomi, Saku, Nagano, 385-0051, Japan

    Takuya Watanabe

  3. Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, 1301 Morris Park Ave., Price 369, Bronx, NY, 10461, USA

    Junichi Okada

  4. Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Eijiro Yamada

  5. Omagari Kousei Medical Center, 8-65 Omagari-torimachi, Daisen, Akita, 014-0027, Japan

    Kazuya Okada

Authors
  1. Shuichi Okada
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  2. Takuya Watanabe
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  3. Junichi Okada
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  4. Eijiro Yamada
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  5. Kazuya Okada
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  6. Koji Kikkawa
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  7. Kihachi Ohsima
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Contributions

TW and SO collected the data. EY, KO (Okada), KK, KO (Ohshima), and SO analyzed the data. JO and SO prepared the manuscript.

Corresponding author

Correspondence to Shuichi Okada.

Ethics declarations

Ethics approval

The ethics committees at Hidaka Hospital and Saku Central Hospital Advanced Care Center approved our study, which conformed to the Declaration of Helsinki (as #355 and R201811-03, respectively).

Informed consent

All patients provided written informed consent to analyze and present their clinical laboratory data.

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All of the authors have also agreed to submit our manuscript to your journal.

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The authors declare no competing interests.

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Okada, S., Watanabe, T., Okada, J. et al. Correlation between insulin resistance score and daily total insulin dosage in patient with type 1 diabetes mellitus: a pilot study. Int J Diabetes Dev Ctries 43, 113–117 (2023). https://doi.org/10.1007/s13410-022-01117-9

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  • DOI: https://doi.org/10.1007/s13410-022-01117-9

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