Abstract
SUMOylation is a dynamic process which can be reversed by a family of sentrin/SUMO-specific protease (SENPs). Recently, SENP1, a member of SENPs family was shown to have a pro-oncogenic role in many types of cancer. Here, we showed that SENP1 was upregulated in pancreatic ductal adenocarcinoma (PDAC) tissues compared with adjacent normal tissues. Moreover, clinical data showed that SENP1 was positively associated with lymph node metastasis and TNM stage. Furthermore, knockdown of SENP1 by SENP1-siRNA inhibited pancreatic cancer cell proliferation, migration, and invasion, suggesting that SENP1 played an important role in PDAC progression and metastasis. Mechanistically, silencing of SENP1 results in downregulation of MMP-9, which is pivotal for PDAC cell growth and migration. Taken together, these results suggest that SENP1 may serve as a potential novel diagnostic and therapeutic target of PDAC.
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Acknowledgments
We thank Professor JK Cheng (The Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine) for the si-SENP1 retrovirus and technical supports. This work was supported in part by Science and Technology Commission of Shanghai Municipality (13JC1407402).
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Ma, C., Wu, B., Huang, X. et al. SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9. Tumor Biol. 35, 12729–12735 (2014). https://doi.org/10.1007/s13277-014-2598-1
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DOI: https://doi.org/10.1007/s13277-014-2598-1