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RNA-mediated regulation of chromatin structures

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Abstract

It is now evident that transcriptional gene regulation usually requires the re-organization of chromatin architecture. Increasing evidence suggested various kinds of RNAs are involved in this process. Especially the nascent RNAs retained at their site of transcription can serve as a scaffold for organizing transcriptionally either favorable or unfavorable chromatin structures. An emerging concept of phase separation explains how these chromatin structures can be maintained as physically discrete subcompartments within membrane-less nucleoplasm. Evidences that support the crucial role of nascent RNAs in the formation of phase-separated condensates are now rapidly growing.

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Acknowledgements

We apologize to all whose excellent works that was not described here due to space limitation. This work was supported by the General Research Fund of the University of Seoul (#201604271104).

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  1. Department of Life Science, University of Seoul, 163 Seoulsiripdae-ro, Dongdaemun-gu, Seoul, 02504, South Korea

    Youngtae Kwon & Yun Doo Chung

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  1. Youngtae Kwon
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Correspondence to Yun Doo Chung.

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Kwon, Y., Chung, Y.D. RNA-mediated regulation of chromatin structures. Genes Genom 42, 609–617 (2020). https://doi.org/10.1007/s13258-020-00929-5

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