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Contextual analysis and the success of translational research

  • Practice and Public Health Policies
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Translational Behavioral Medicine

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Abstract

The success of translational research can ultimately be judged by the degree to which it reduces the incidence and prevalence of psychological, behavioral, and physical disorders and the major factors influencing them. In our view, we currently place insufficient emphasis on assessing our impact on the social determinants of disorders. As a result, we are failing to affect the incidence and prevalence of critical disorders. Moreover, translational research fails to take into account the full range of interventions that could significantly reduce the incidence and prevalence of our most pressing disorders. These include policy changes, media, and broad cultural change movements. In this paper, we discuss the momentous achievements the tobacco prevention movement made over the last half-century, describe how the lessons gleaned from this success can apply to other prevention efforts, and contrast this success with progress made in battling other major public health concerns. We call for an expansion of the translational research agenda to develop and evaluate broader and more comprehensive strategies to affect well-being in entire populations.

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References

  1. National Institute on Drug Abuse. Nationwide trends. Retrieved April 7, 2015 from http://www.drugabuse.gov/publications/drugfacts/nationwide-trends.

  2. Pratt LA, Brody DJ. Depression in the U. S. household population, 2005–2006. NCHS Data Brief No. 7. U.S. Department of Health & Human Services, National Center for Health Statistics; 2008. Available at http://www.cdc.gov/nchs/data/databriefs/db07.htm.

  3. Pratt LA, Brody DJ. Depression in the U. S. household population, 2009–2012. NCHS Data Brief No. 172. U.S. Department of Health & Human Services, NDHS; 2014. Available at http://www.cdc.gov/nchs/data/databriefs/db172.pdf.

  4. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA. 2012; 307: 491-497. Available at http://jama.ama-assn.org/content/307/5/491.

  5. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999–2010. JAMA. 2012; 307: 483-490. Available at http://jama.ama-assn.org/content/307/5/483.

  6. Centers for Disease Control. (2013). Age-adjusted incidence of diagnosed diabetes per 1,000 population aged 18–79 years, by sex, United States, 1980–2011. Available at http://www.cdc.gov/diabetes/statistics/incidence/fig4.htm.

  7. Whitaker R. Anatomy of an epidemic. New York: Crown; 2010.

    Google Scholar 

  8. Halfon N, Houtrow A, Larson K, Newacheck PW. The changing landscape of disability in childhood. Fut Child. 2012; 22: 13-42.

    Article  Google Scholar 

  9. Flay BR. 1987. Evaluation of the development, dissemination, and effectiveness of mass media health programming. Hlth Educ Res. 1987; 2: 123-129.

    Google Scholar 

  10. Fishbein DH, Sussman S, Ridenour T, Stahl M. Translating emerging research into prevention of high-risk behaviors: state-of-the-science, barriers, and innovations. In special issue: Translational Beh Med. In press.

  11. Gottfredson DC, Cook TD, Gardner FEM, et al. Standards of evidence for efficacy, effectiveness, and scale-up research in prevention science: next generation. Preve Sci. under review.

  12. Greenwald P, Cullen JW. The scientific approach to cancer control. CA: Cancer J Clin. 1984; 34: 328-332.

    CAS  Google Scholar 

  13. Mrazek PJ, Haggerty RJ. Reducing risks for mental disorders: frontiers for preventive intervention research. Washington, DC: National Academy Press; 1994.

    Google Scholar 

  14. Spoth R, Rohrbach LA, Greenberg M, et al. Addressing core challenges for the next generation of type 2 translation research and systems: The translation science to population impact (TSci Impact) framework. Prev Sci. 2013; 14: 319-351.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Institute of Medicine. Ending the tobacco problem: a blueprint for the nation. Washington, DC: The National Academies Press; 2007.

    Google Scholar 

  16. U. S. Department of Health and Human Services. Preventing tobacco use among youth and young adults: a report of the Surgeon General. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2012.

  17. Gordon J, Biglan A, Smolkowski K. The impact on tobacco use of branded youth anti-tobacco activities and family communications about tobacco. Prev Sci. 2008; 9: 73-87.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Lichtenstein E, Glasgow RE. Rapid smoking: side effects and safeguards. JCCP. 1977; 45: 815-821.

    CAS  Google Scholar 

  19. Lichtenstein E, Rodrigues MR. Long-term effects of rapid smoking treatment for dependent cigarette smokers. Addict Beh. 1977; 2: 109-112.

    Article  CAS  Google Scholar 

  20. Lichtenstein E, Zhu SH, Tedeschi GJ. Smoking cessation quitlines: an under-recognized intervention success story. Am Psychol. 2010; 65: 252-261.

    Article  PubMed  PubMed Central  Google Scholar 

  21. National Cancer Institute. The role of the media in promoting and reducing tobacco use. Tobacco Control Monograph No. 19. Bethesda, MD: U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute; 2008.

  22. Eubanks SY, Glantz SA. Bad acts: the racketeering case against the tobacco industry. Washington, DC: APHA; 2012.

    Google Scholar 

  23. Chaloupka FJ, Yurekli A, Fong GT. Tobacco taxes as a tobacco control strategy. Tob Ctrl. 2012; 21: 172-180.

    Google Scholar 

  24. Lichtenstein E, Glasgow RE. Smoking cessation: what have we learned over the past decade? JCCP. 1992; 60: 518-527.

    CAS  Google Scholar 

  25. Babor T. Alcohol: no ordinary commodity: research and public policy. Oxford: University Press; 2010.

    Book  Google Scholar 

  26. Biglan A. The nurture effect: how the science of human behavior can improve our lives and our world. New Harbinger: Oakland, CA; 2015.

    Google Scholar 

  27. Organization for Economic Cooperation and Development. Doing better for children. Available at http://www.oecd.org/els/family/doingbetterforchildren.htm. Accessibility verified May 13, 2015.

  28. Galea S, Tracy M, Hoggatt KJ, DiMaggio C, Karpati A. Estimated deaths attributable to social factors in the United States. Am J Pub Health. 2011; 101: 1456-1465.

    Article  Google Scholar 

  29. Galobardes B, Lynch JW, Smith GD. Is the association between childhood socioeconomic circumstances and cause-specific mortality established? Update of a systematic review. J Epidemiol Comm Health. 2008; 62: 387-390.

    Article  CAS  Google Scholar 

  30. Yoshikawa H, Aber JL, Beardslee WR. The effects of poverty on the mental, emotional, and behavioral health of children and youth: implications for prevention. Am Psychol. 2012; 67: 272-284.

    Article  PubMed  Google Scholar 

  31. Olds DL, Henderson CR Jr, Tatelbaum R, Chamberlin R. Improving the life-course development of socially disadvantaged mothers: a randomized trial of nurse home visitation. Am J Pub Health. 1988; 78: 1436-1445.

    Article  CAS  Google Scholar 

  32. Patterson GR, Forgatch MS, DeGarmo DS. Cascading effects following intervention. Devel Psychopath. 2010; 22: 949-970.

    Article  Google Scholar 

  33. Fishbein DH. The importance of neurobiological research to the prevention of psychopathology. Prev Sci. 2000; 1: 89-106.

    Article  CAS  PubMed  Google Scholar 

  34. Biglan A, Hayes SC. Should the behavioral sciences become more pragmatic? The case for functional contextualism in research on human behavior. Appl Prev Psychol. 1996; 5: 47-57.

    Article  Google Scholar 

  35. Biglan A, Hayes SC. Functional contextualism and contextual behavioral science. In: Hayes S, Barnes-Homes D, Zettle R, Biglan A, eds. The Wiley Handbook of Contextual Behavioral Science. Wiley: New York; 2016.

  36. Fillmore MT, Weafer J. Impaired inhibitory control as a mechanism of drug abuse. In: Inhibitory Control and Drug Abuse Prevention. New York: Springer; 2011: 85-100.

    Chapter  Google Scholar 

  37. Volkow ND, Skolnick P. New medications for substance use disorders: challenges and opportunities. Neuropsychopharmacology. 2012; 37: 290-292.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Barnes-Holmes D. Behavioral pragmatism: no place for reality and truth. Beh Anal. 2000; 23: 191-202.

    CAS  Google Scholar 

  39. Hayes SC, Barnes-Holmes D, Wilson KG. Contextual behavioral science: creating a science more adequate to the challenge of the human condition. J Contextual Beh Sci. 2012; 1: 1-16.

    Article  Google Scholar 

  40. Mrazek P, Biglan A, Hawkins JD. Community-monitoring systems: tracking and improving the well-being of America’s children and adolescents. Falls Church: Society for Prevention Research; 2005.

    Google Scholar 

  41. Chyou PH, Nomura AM, Stemmermann GN. A prospective study of the attributable risk of cancer due to cigarette smoking. Am J Pub Health. 1992; 82: 37-40.

    Article  CAS  Google Scholar 

  42. Biglan A, Flay BR, Embry DD, Sandler I. Nurturing environments and the next generation of prevention research and practice. Am Psychol. 2012; 67: 257-271.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Dobson KS, Dozois DJA, eds. Risk factors in depression. San Diego: Elsevier Academic Press; 2008.

    Google Scholar 

  44. Wilkinson R, Pickett K. The spirit level: why greater equality makes societies stronger. London: Bloomsbury Press; 2009.

    Google Scholar 

  45. Finkelhor D, Turner H, Ormrod R, Hamby SL. Violence, abuse, and crime exposure in a national sample of children and youth. Pediatrics. 2009; 124: 1411-1423.

    Article  PubMed  Google Scholar 

  46. Biglan A. Selection by consequences: one unifying principle for a transdisciplinary science of prevention. Prev Sci. 2003; 4: 213-232.

    Article  PubMed  Google Scholar 

  47. Biglan A, Ary D, Wagenaar AC. The value of interrupted time-series experiments for community intervention research. Prev Sci. 2000; 1: 31-49.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Lindsey-Pengelly, L., Toobert, D., Ramirez Garcia, J. I., Biglan, T., Van Ryzin, M., & Strycker L. A. Progress in the development of integrated care: challenges and recommendations from the Trillium Integration and Incubation Program.

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Acknowledgments

National Institute on Alcohol Abuse and Alcoholism (R01AA021726-01A1) provided financial support for the completion of the work on this manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIAAA or the National Institutes of Health. The authors would like to thank Christine Cody for her editorial input.

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Correspondence to Anthony Biglan PhD.

Ethics declarations

All procedures of the funded project, including the informed consent process, were conducted in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national).

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The authors declare that they have no competing interests.

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Implications

Research: Researchers will be able to expand their research agenda to develop and evaluate broader, more comprehensive strategies that can affect well-being in the entire populations they encounter.

Practice: Practitioners will begin to pay critical attention to assessing our impact on the social determinants of critical disorders, which will have positive effects on the incidence and prevalence of these disorders.

Policy: The momentous achievements the tobacco prevention movement made over the last half-century can apply to other prevention efforts, policies, and social movements

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Biglan, A., Levin, M.E. Contextual analysis and the success of translational research. Behav. Med. Pract. Policy Res. 6, 160–166 (2016). https://doi.org/10.1007/s13142-015-0362-8

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