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[68 Ga]Ga-PSMA-11 Small Bowel Uptake in Crohn’s Disease: Revisiting the “Non-specificity” of PSMA Ligands

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Abstract

The rapidly evolving clinical utility of prostate-specific membrane antigen (PSMA) PET/CT as an imaging modality for prostate cancer (PCa) has brought to the forefront a multitude of non-prostatic diseases also exhibiting PSMA radioligand uptake. We report a case of a 71-year-old male with PCa who underwent PSMA PET/CT for recurrence evaluation. The scan demonstrated [68 Ga]Ga-PSMA-11 uptake in the distal ileum. Retrospective enquiry revealed that the patient was a known case of Crohn’s disease. This case highlights an uncommon finding of PSMA radioligand uptake in the distal small bowel (non-prostatic benign pathological uptake) in a patient with known Crohn’s disease, which may be misinterpreted in the evaluation of PCa.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Kunal Ramesh Chandekar, Sindhu Tanigassalam, Anwin Joseph Kavanal, Harmandeep Singh & Anish Bhattacharya

  2. Department of Urology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Ravimohan Suryanarayan Mavuduru

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  1. Kunal Ramesh Chandekar
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  2. Sindhu Tanigassalam
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  3. Anwin Joseph Kavanal
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  4. Harmandeep Singh
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  6. Ravimohan Suryanarayan Mavuduru
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Contributions

Material preparation and data collection were performed by Kunal Ramesh Chandekar and Sindhu Tanigassalam. The first draft of the manuscript was written by Kunal Ramesh Chandekar. Revision and editing of the manuscript was done by Anwin Joseph Kavanal, Harmandeep Singh, and Anish Bhattacharya. The referring urologist in charge was Ravimohan Suryanarayan Mavuduru who helped in the final revision. All authors have read and approved the final manuscript.

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Correspondence to Harmandeep Singh.

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Kunal Ramesh Chandekar, Sindhu Tanigassalam, Anwin Joseph Kavanal, Harmandeep Singh, Anish Bhattacharya, and Ravimohan Suryanarayan Mavuduru declare no coflict of interest.

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This article is to be considered for publication under the Case Report category. Hence, ethical approval is not applicable.

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Informed consent of the subject was obtained as per departmental protocol.

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Chandekar, K.R., Tanigassalam, S., Kavanal, A.J. et al. [68 Ga]Ga-PSMA-11 Small Bowel Uptake in Crohn’s Disease: Revisiting the “Non-specificity” of PSMA Ligands. Nucl Med Mol Imaging 56, 102–104 (2022). https://doi.org/10.1007/s13139-021-00732-4

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  • DOI: https://doi.org/10.1007/s13139-021-00732-4

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