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Expression of Prostate-Specific Membrane Antigen in Normal and Malignant Human Tissues

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Abstract

Background

Prostate-specific membrane antigen (PSMA) is upregulated in androgen-dependent prostate carcinoma and it has been targeted for immunotherapy and diagnosis of this cancer. However, this protein is also expressed in other tissues. The objective of this study is to investigate its expression in normal and malignant human tissues.

Methods

Using monoclonal antibodies 24.4E6 (specific for residues 638–657) and 7E11.C5 (specific for the transmembrane domain of PSMA), immunohistochemical detection of PSMA was performed in surgical specimens.

Results

Prostate-specific membrane antigen was detected in the epithelium of prostate, urinary bladder, proximal tubules of kidney, liver, esophagus, stomach, small intestine, colon, breast, fallopian tubes and testicular seminiferous tubules, hippocampal neurons and astrocytes, ependyma, cortex and medulla of the adrenal gland, and ovary stroma. It was also detected in neoplasms of the prostate, kidney, urinary bladder, stomach, small intestine, colon, lung, adrenal gland, and testis. It was not detected in normal seminal vesicles or the lung.

Conclusions

These findings demonstrate that PSMA is widely distributed in normal tissues, and, depending on the tumors, its expression is up- or down-regulated, or unchanged. The broad distribution of PSMA may make it suitable for the diagnosis and therapy of a wide variety of tumors.

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Acknowledgements

This study was supported in part by the NIH grant 1RO1AG21389-01 and by the Veterans Administration.

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Authors and Affiliations

  1. Department of Urology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA

    Yoshihisa Kinoshita MD, PhD, Katsuyuki Kuratsukuri MD, PhD, Peter M. Rovito Jr. BS, Ching Y. Wang DVM, PhD & Gabriel P. Haas MD

  2. Department of Urology, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno ku, Osaka, 545-8585, Japan

    Yoshihisa Kinoshita MD, PhD & Katsuyuki Kuratsukuri MD, PhD

  3. Department of Pathology, SUNY Upstate Medical University, 750 East Adams street, Syracuse, NY, 13210, USA

    Steve Landas MD

  4. Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Kagawa, Japan

    Katsumi Imaida MD

  5. VA Medical Center Irving Avenue, Syracuse, NY, 13210, USA

    Gabriel P. Haas MD

Authors
  1. Yoshihisa Kinoshita MD, PhD
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  2. Katsuyuki Kuratsukuri MD, PhD
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  3. Steve Landas MD
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  4. Katsumi Imaida MD
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  5. Peter M. Rovito Jr. BS
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  6. Ching Y. Wang DVM, PhD
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  7. Gabriel P. Haas MD
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Corresponding author

Correspondence to Yoshihisa Kinoshita MD, PhD.

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Kinoshita, Y., Kuratsukuri, K., Landas, S. et al. Expression of Prostate-Specific Membrane Antigen in Normal and Malignant Human Tissues. World J. Surg. 30, 628–636 (2006). https://doi.org/10.1007/s00268-005-0544-5

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  • DOI: https://doi.org/10.1007/s00268-005-0544-5

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