Skip to main content
Log in

Targeting Mfsd2a in hemorrhagic cerebrovascular diseases

  • Letter to the Editor
  • Published:
Translational Stroke Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Cohen AW, Hnasko R, Schubert W, Lisanti MP. Role of caveolae and caveolins in health and disease. Physiol Rev. 2004;84:1341–79. https://doi.org/10.1152/physrev.00046.2003.

    Article  CAS  PubMed  Google Scholar 

  2. Eser Ocak P, Ocak U, Tang J, Zhang JH. The role of caveolin-1 in tumors of the brain - functional and clinical implications. Cell Oncol. 2019;42(4):423–47. https://doi.org/10.1007/s13402-019-00447-x.

    Article  CAS  Google Scholar 

  3. Angers M, Uldry M, Kong D, Gimble JM, Jetten AM. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem J. 2008;416(3):347–55. https://doi.org/10.1042/BJ20080165.

    Article  CAS  PubMed  Google Scholar 

  4. Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh EL, Silver DL. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature. 2014;509(7501):503–6. https://doi.org/10.1038/nature13241.

    Article  CAS  PubMed  Google Scholar 

  5. Eser Ocak P, Ocak U, Sherchan P, Zhang JH, Tang J. Insights into major facilitator superfamily domain- containing protein-2a (Mfsd2a) in physiology and pathophysiology. What do we know so far? J Neurosci Res. 2020;98(1):29–41. https://doi.org/10.1002/jnr.24327.

    Article  CAS  Google Scholar 

  6. Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H, Gu C. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature. 2014;509(7501):507–11. https://doi.org/10.1038/nature13324.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Huang B, Li X. The Role of Mfsd2a in Nervous System Diseases. Front Neurosci. 2021;15: 730534. https://doi.org/10.3389/fnins.2021.730534.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Yang YR, Xiong XY, Liu J, Wu LR, Zhong Q, Zhou K, Meng ZY, Liu L, Wang FX, Gong QW, Liao MF, Duan CM, Li J, Yang MH, Zhang Q, Gong CX, Yang QW. Mfsd2a (major facilitator superfamily domain containing 2a) attenuates intracerebral hemorrhage-induced blood-brain barrier disruption by inhibiting vesicular transcytosis. J Am Heart Assoc. 2017;6(7): e005811. https://doi.org/10.1161/JAHA.117.005811.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Eser Ocak P, Ocak U, Sherchan P, Gamdzyk M, Tang J, Zhang JH. Overexpression of Mfsd2a attenuates blood brain barrier dysfunction via Cav-1/Keap-1/Nrf-2/HO-1 pathway in a rat model of surgical brain injury. Exp Neurol. 2020;326: 113203. https://doi.org/10.1016/j.expneurol.2020.113203.

    Article  CAS  PubMed  Google Scholar 

  10. Zhao C, Ma J, Wang Z, Li H, Shen H, Li X, Chen G. Mfsd2a attenuates blood-brain barrier disruption after sub-arachnoid hemorrhage by inhibiting caveolae-mediated transcellular transport in rats. Transl Stroke Res. 2020;11(5):1012–27. https://doi.org/10.1007/s12975-019-00775-y.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Pinar Eser.

Ethics declarations

Ethics Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Eser, P., Taskapilioglu, M.O. & Kocaeli, H. Targeting Mfsd2a in hemorrhagic cerebrovascular diseases. Transl. Stroke Res. 13, 861–862 (2022). https://doi.org/10.1007/s12975-022-01015-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12975-022-01015-6

Navigation