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Treatment of Tension-Type Headaches in Adolescents (14–15 Years Old): the Efficacy of Aminophenylbutyric Acid Hydrochloride

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Abstract

The paper represents a modern view on the problem of tension-type headache (TTH) in adolescents, which is caused by the following factors: information overload and other types of stress, sleep deprivation, and physical activity deficiency, impaired posture with myogenic trigger points developing. The research covered 64 adolescents aged 14–15 with tension-type headaches: 33 boys and 42 girls (11 boys and 20 girls with frequent episodic tension-type headache (ETTH) and 12 boys and 21 girls with chronic tension-type headache (CTTH)). We assessed accompanying symptoms over the last 6 months according to the Likert scale. All children were prescribed GABA receptor agonist—aminophenylbutyric acid hydrochloride 250 mg three times a day for 3 weeks. The reduction of tension-type headache intensity was assessed by 3-grade scale: “no change,” “significantly reduced,” and “completely stopped”: 0—no, 1—very seldom, 2—often, and 3—permanently. ETTH/CTTH associated symptoms are as follows: (1) difficulty of falling asleep and restless sleep (0.91 ± 0.83/1.54 + 1.26), (2) difficulty of concentrating during the day (0.61 + 0.92/2.04 + 1.21), (3) morning sickness (0.32 + 0.87/1.81 + 1.29), (4) feeling ill in the morning with improvement in the second half of the day (0.17 + 0.57/1 95 + 0.95), (5) meteosensitivity (0.58 + 1.01/1.59 + 1.22), and (6) decrease in physical capability (0.20 + 0.64/1.72 + 0.82). After 3 weeks, the pain in ETTH subgroup completely stopped in 27 children (79%) and significantly reduced in 7 (21%). In CTTH subgroup, the pain completely stopped in 9 children (41%) and significantly reduced in 13 (59%). Associated symptoms of ETTH/CTTH are as follows: (1) difficulty of falling asleep and restless sleep (0.26 + 0.44, p = 0.000093/0.45 + 0.80, p = 0.000224), (2) difficulty of concentrating during the day (0.17 + 0.38, p = 0.003707/0.54 + 0.85; p = 0.000007), (3) morning sickness (0.08 + 0.28, p = 0. 058101/0.77 + 1.06, p = 0.001682), (4) feeling ill in the morning with improvement in the second half of the day (0.08 + 0.28, p = 0.083119/0.27 + 0.45; p = 0.000000), (5) meteosensitivity (0.32 + 0.63, p = 0.010304/1.36 + 1.09, p = 0.021450), and (6) decrease in physical capability (0.058 + 0 23; p = 0.133706 / 0.95 + 1.04, p = 0.005055). Aminophenylbutyric acid hydrochloride (GABA receptor agonist) reduces the intensity of tension-type headache and has a positive effect on associated symptoms. It can be recommended for inclusion into the scheme of tension-type headache treatment in schoolchildren.

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References

  1. Abu-Arafeh, I., Razak, S., Sivaraman, B., & Graham, C. (2010). Prevalence of headache and migraine in children and adolescents: a systematic review of population-based studies. Developmental Medicine & Child Neurology., 52, 1088–1097.

    Article  Google Scholar 

  2. Blume H. (2012). Pediatric headache: a review. Pediatrics in Review 2012; 33(12): 562–576. https://doi.org/10.1542/pir.33-12-562.

  3. Karli, N., Akgoz, S., Zarifoglu, M., et al. (2006). Clinical characteristics of tension-type headache and migraine in adolescents: a student-based study. Headache, 46(3), 399–412.

    Article  Google Scholar 

  4. Akyol, A., Kiylioglu, N., Aydin, I., et al. (2007). Epidemiology and clinical characteristics of migraine among school children in the Menderes region. Cephalalgia, 27(7), 781–787.

    Article  Google Scholar 

  5. Sillanpaa, M., Piekkala, P., & Kero, P. (1991). Prevalence of headache at preschool age in an unselected child population. Cephalalgia, 11(5), 239–242.

    Article  Google Scholar 

  6. Fearon, P., & Hotopf, M. (2001). Relation between headache in childhood and physical and psychiatric symptoms in adulthood: national birth cohort study. BMJ, 322(7295), 1145.

    Article  Google Scholar 

  7. Bugdayci, R., Ozge, A., Sasmaz, T., et al. (2005). Prevalence and factors affecting headache in Turkish schoolchildren. Pediatrics International, 47(3), 316–322.

    Article  Google Scholar 

  8. Headache Classification Committee of the International Headache Society. (2013). The international classification of headache disorders, 3rd edition (beta version). Cephalalgia, 33(9), 629–808.

    Article  Google Scholar 

  9. Likert, R. (1932). A technique for the measurement of attitudes. Archives of Psychology, 140, 1–55.

    Google Scholar 

  10. Simons, D., Travell, J., Simons, L., & Travell, J. (1999). Myofascial pain and dysfunction. Baltimore: Williams & Wilkins.

    Google Scholar 

  11. Esin, O. R., Esin, R. G., Tukhbatulin, M. G., Nasirtdinova, A. M., & Sakhapova, L. R. (2014). Muscular-arterial nociceptive reflex in patients with primary headaches. Zh Nevrol Psikhiatr Im S.S.Korsakova 2014, 114(1), 13–15.

    Google Scholar 

  12. Rahim, A., & Seffinger, M. (2016). Myofascial trigger point release massage therapy relieves tension-type headaches. The Journal of the American Osteopathic Association., 116(1), 55. https://doi.org/10.7556/jaoa.2016.009

    Article  Google Scholar 

  13. Strine, T. W., Okoro, C. A., McGuire, L. C., & Balluz, L. S. (2006). The associations among childhood headaches, emotional and behavioral difficulties, and health care use. Pediatrics, 117(5), 1728–1735.

    Article  Google Scholar 

  14. Mazzone, L., Vitiello, B., Incorpora, G., & Mazzone, D. (2006). Behavioral and temperamental characteristics of children and adolescents suffering from primary headache. Cephalalgia, 26(2), 194–201.

    Article  Google Scholar 

  15. Derdikman-Eiron, R., Indredavik, M. S., Bratberg, G. H., et al. (2011). Gender differences in subjective well-being, self-esteem and psychosocial functioning in adolescents with symptoms of anxiety and depression: findings from the Nord-Trondelag Health Study. Scandinavian Journal of Psychology, 52, 261–267.

    Article  Google Scholar 

  16. Claar, R. L., Baber, K. F., Simons, L. E., et al. (2008). Pain coping profiles in adolescents with chronic pain. Pain, 140, 368–375.

    Article  Google Scholar 

  17. Greenlee D., van Ness P., Olsen R. (2004). Endogenous inhibitor of GABA binding in mammalian brain. Life Sciences. 1978;22(18):1653–1662. https://doi.org/10.1016/0024-3205(78)90062-0.

  18. Bowery, N., Enna, S., & Olsen, R. Six decades of GABA. Biochemical Pharmacology, 68(8), 1477–1478. https://doi.org/10.1016/j.bcp.2004.07.033

  19. Lapin, I. (2006). Phenibut (β-Phenyl-GABA): a tranquilizer and nootropic drug. CNS Drug Reviews 2006, 7(4), 471–481. https://doi.org/10.1111/j.1527-3458.2001.tb00211.x

    Article  Google Scholar 

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Acknowledgements

The reported study was supported by the program of competitive growth of Kazan Federal University.

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Authors and Affiliations

  1. Laboratory of Clinical Linguistics, Kazan Federal University, 2 Tatarstan str, Kazan, Russian Federation, 420008

    Oleg Radievich Esin

  2. University Clinic, Kazan Federal University, 1a Chekov str, Kazan, Russian Federation, 420012

    Oleg Radievich Esin

  3. Department of Russian Language and Applied Linguistics, Kazan Federal University, 2 Tatarstan str, Kazan, Russian Federation, 420008

    Oleg Radievich Esin

  4. Institute of Fundamental Medicine and Biology, Kazan Federal University, 56 K. Marks str, Kazan, Russian Federation, 420012

    Oleg Radievich Esin

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Correspondence to Oleg Radievich Esin.

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Esin, O.R. Treatment of Tension-Type Headaches in Adolescents (14–15 Years Old): the Efficacy of Aminophenylbutyric Acid Hydrochloride. BioNanoSci. 8, 418–422 (2018). https://doi.org/10.1007/s12668-018-0507-6

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