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Update of Wnt signaling in implantation and decidualization

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Reproductive Medicine and Biology

Abstract

Embryonic development into an implantation-competent blastocyst, synchronized uterine transformation into a receptive stage, and an intimate cross-talk between the activated blastocyst and the receptive uterus are essential for successful implantation, and therefore for subsequent pregnancy outcome. Evidence accumulating during recent years has underlined the importance of the Wnt signaling pathway in mammalian implantation and decidualization. Herein, this review focuses on the current state of knowledge regarding Wnt signaling in multiple implantation and decidualization events: pre-implantation embryo development, blastocyst activation for implantation, uterine development, and decidualization.

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Acknowledgments

This work was supported by Natural Science Foundation of Shandong Province [ZR2014HM089].

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Authors and Affiliations

  1. Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China

    Qian Zhang & Junhao Yan

  2. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China

    Qian Zhang & Junhao Yan

  3. The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China

    Qian Zhang & Junhao Yan

  4. Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China

    Qian Zhang & Junhao Yan

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  1. Qian Zhang
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Zhang, Q., Yan, J. Update of Wnt signaling in implantation and decidualization. Reprod Med Biol 15, 95–105 (2016). https://doi.org/10.1007/s12522-015-0226-4

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