Abstract
This mini-review highlights cardiovascular studies that were presented during the Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2019 annual meeting in Anaheim, California. The aim is to provide the readers insight to noteworthy studies related to the fields of nuclear cardiology presented during the conference. Although cardiovascular applications of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are not the primary focus of the SNMMI, several scientific teams working in this field presented their latest findings in Anaheim. While this review is directed to the benefit of those who were not able to attend the annual meeting, we believe that a general overview may also be useful for those who did attend as it is often difficult to get exposure to all the high-quality abstracts presented at this large conference.
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Abbreviations
- SPECT:
-
Single Photon Emission Computed Tomography
- PET:
-
Positron Emission Tomography
- CT:
-
Computed Tomography
- PIB:
-
Pittsburgh Compound B
- 18F-TTP:
-
18F-triphenylphosphonium
- MRI:
-
Magnetic Resonance Imaging
- TBR:
-
Target to Background Ratio
- MPI:
-
Myocardial Perfusion Imaging
References
Delgado V, Bucciarelli-Ducci C, Gaemperli O, et al. Multimodality imaging: Bird’s eye view from The European Society of Cardiology Congress 2018 Munich, August 25–29, 2018. J Nucl Cardiol. 2019;26:76–85. https://doi.org/10.1007/s12350-018-01517-7.
Al-Mallah MH, Lloyd SG, Doukky R, et al. Multi-modality imaging: Bird’s eye view from the 2018 American Heart Association Scientific Sessions. J Nucl Cardiol. 2019;26:645–54. https://doi.org/10.1007/s12350-019-01603-4.
Lloyd S, Blankstein R, Van Decker WA, Garcia M. Multimodality imaging: Bird’s eye view from The American College of Cardiology Annual Scientific Meeting 2017, Washington DC March 17 to 19, 2017. J Nucl Cardiol. 2018;25:331–5. https://doi.org/10.1007/s12350-017-1123-5.
Döring Y, Pawig L, Weber C, Noels H. The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease. Front Physiol. 2014;5:1–23. https://doi.org/10.3389/fphys.2014.00212.
Demmer O, Gourni E, Schumacher U, et al. PET imaging of CXCR5 receptors in cancer by a new optimized ligand. ChemMedChem. 2011;6:1789–91. https://doi.org/10.1002/cmdc.201100320.
Hyafil F, Pelisek J, Laitinen I, et al. Imaging the cytokine receptor CXCR6 in atherosclerotic plaques with the radiotracer 68 Ga-Pentixafor for PET. J Nucl Med. 2017;58:499–506. https://doi.org/10.2967/jnumed.116.179663.
Alpert NM, Guehl N, Ptaszek L, et al. Quantitative in vivo mapping of myocardial mitochondrial membrane potential. PLoS ONE. 2018;13:e0190968.
Lee SP, Lee ES, Choi H, et al. 11C-Pittsburgh B PET imaging in cardiac amyloidosis. JACC Cardiovasc Imaging. 2015;8:50–9. https://doi.org/10.1016/j.jcmg.2014.09.018.
Fallavollita JA, Heavey BM, Luisi AJ, et al. Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy. J Am Coll Cardiol. 2014;63:141–9. https://doi.org/10.1016/j.jacc.2013.07.096.
Jacobson AF, Senior R, Cerqueira MD, et al. Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView myocardial imaging for risk evaluation in heart failure) study. J Am Coll Cardiol. 2010;55:2212–21. https://doi.org/10.1016/j.jacc.2010.01.014.
Hasan W. Autonomic cardiac innervation: Development and adult plasticity. Organogenesis. 2013;9:129–46. https://doi.org/10.4161/org.24892.
Fukuda K, Kanazawa H, Aizawa Y, et al. Cardiac innervation and sudden cardiac death. Circ Res. 2015;116:2005–19. https://doi.org/10.1161/CIRCRESAHA.116.304679.
Volkova M, Russell R. Anthracycline cardiotoxicity: Prevalence, pathogenesis and treatment. Curr Cardiol Rev. 2011;7:214–20.
Swain SM, Whaley FS, Ewer MS. Congestive heart failure in patients treated with doxorubicin: A retrospective analysis of three trials. Cancer. 2003;97:2869–79. https://doi.org/10.1002/cncr.11407.
Jordan JH, Vasu S, Morgan TM, et al. Anthracycline-associated T1 mapping characteristics are elevated independent of the presence of cardiovascular comorbidities in cancer survivors. Circ Cardiovasc Imaging. 2016;9:1–9. https://doi.org/10.1161/CIRCIMAGING.115.004325.
Wu J, Boutagy N, Feher A, et al. Dynamic SPECT imaging of 123I-mIBG for early detection of doxorubicin-induced cardiotoxicity in dogs. J Nucl Med. 2018;59:101.
Soussan M, Brillet PY, Nunes H, et al. Clinical value of a high-fat and low-carbohydrate diet before FDG-PET/CT for evaluation of patients with suspected cardiac sarcoidosis. J Nucl Cardiol. 2013;20:120–7. https://doi.org/10.1007/s12350-012-9653-3.
Scholtens AM, Verberne HJ, Budde RPJ, Lam MGEH. Additional heparin preadministration improves cardiac glucose metabolism suppression over low-carbohydrate diet alone in 18F-FDG PET imaging. J Nucl Med. 2016;57:568–73. https://doi.org/10.2967/jnumed.115.166884.
Manabe O, Yoshinaga K, Ohira H, et al. The effects of 18-h fasting with low-carbohydrate diet preparation on suppressed physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake and possible minimal effects of unfractionated heparin use in patients with suspected cardiac involvement sarcoidosis. J Nucl Cardiol. 2016;23:244–52. https://doi.org/10.1007/s12350-015-0226-0.
Goel S, Bommireddipalli S, DePuey EG. Effect of proton pump inhibitors and H2 antagonists on the stomach wall in 99mTc-sestamibi cardiac imaging. J Nucl Med Technol. 2009;37:240–3. https://doi.org/10.2967/jnmt.109.065847.
Kwiecinski J, Berman DS, Lee S-E, et al. Three-hour delayed imaging improves assessment of coronary 18 F-sodium fluoride PET. J Nucl Med. 2018. https://doi.org/10.2967/jnumed.118.217885&link_type=del_icio_us.
Berman DS, Maddahi J, Tamarappoo BK, et al. Phase II safety and clinical comparison with single-photon emission computed tomography myocardial perfusion imaging for detection of coronary artery disease: Flurpiridaz F 18 positron emission tomography. J Am Coll Cardiol. 2013;61:469–77. https://doi.org/10.1016/j.jacc.2012.11.022.
Maddahi J, Packard RRS. PET should replace SPECT in cardiac imaging for diagnosis and risk assessment of patients with known or suspected CAD: Pro. J Nucl Cardiol. 2017;24:1955–9. https://doi.org/10.1007/s12350-015-0300-7.
Nekolla SG, Reder S, Saraste A, et al. Evaluation of the novel myocardial perfusion positron-emission tomography tracer 18F-BMS-747158-02: Comparison to 13N-ammonia and validation with microspheres in a pig model. Circulation. 2009;119:2333–42. https://doi.org/10.1161/CIRCULATIONAHA.108.797761.
Gould KL, Johnson NP, Bateman TM, et al. Anatomic versus physiologic assessment of coronary artery disease: Role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making. J Am Coll Cardiol. 2013;62:1639–53. https://doi.org/10.1016/j.jacc.2013.07.076.
Sharma P, Patel CD, Karunanithi S, et al. Comparative accuracy of CT attenuation-corrected and non–attenuation-corrected SPECT myocardial perfusion imaging. Clin Nucl Med. 2012;37:332–8.
Bellinge JW, Francis RJ, Majeed K, et al. In search of the vulnerable patient or the vulnerable plaque: 18 F-sodium fluoride positron emission tomography for cardiovascular risk stratification. J Nucl Cardiol. 2018;25:1774–83. https://doi.org/10.1007/s12350-018-1360-2.
Lassen ML, Kwiecinski J, Cadet S, et al. Data-driven gross patient motion detection and compensation: implications for coronary 18 F-NaF PET imaging. J Nucl Med. 2018. https://doi.org/10.2967/jnumed.118.217877.
Lassen ML, Beyer T, Berger A, et al. Data-driven, projection-based respiratory motion compensation of PET data for cardiac PET / CT and PET / MR imaging. J Nucl Cardiol. 2019. https://doi.org/10.1007/s12350-019-01613-2.
Rubeaux M, Joshi NV, Dweck MR, et al. Motion correction of 18F-NaF PET for imaging coronary atherosclerotic plaques. J Nucl Med. 2016;57:54–9. https://doi.org/10.2967/jnumed.115.162990.
Disclosures
Piotr Slomka receives software royalties for Quantitative Perfusion SPECT (QPS) software from Cedars-Sinai Medical Center. The other authors have nothing to disclose.
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Kwiecinski, J., Lassen, M.L., Liang, J. et al. Selection of abstracts from the scientific sessions of The Society Of Nuclear Medicine and Molecular Imaging annual meeting Anaheim CA. J. Nucl. Cardiol. 26, 1667–1673 (2019). https://doi.org/10.1007/s12350-019-01816-7
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DOI: https://doi.org/10.1007/s12350-019-01816-7