Abstract
In this issue, Suh’s group reported a new formal total synthesis of (±)-grandisol featuring a palladium-catalyzed 4-exo-trig cyclization. Grandisol’s interesting cyclobutane structure has been a popular test model for various cyclization methods over the years. This report summarizes Suh’s formal synthesis of grandisol along with a concise review of the four-membered ring cyclization strategies employed in the synthesis of grandisol.
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Kwak, YS., Jeong, BS. Synthesis of grandisol, the sexual attracting insect pheromone. Arch. Pharm. Res. 34, 1399–1402 (2011). https://doi.org/10.1007/s12272-011-0900-y
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DOI: https://doi.org/10.1007/s12272-011-0900-y