Abstract
A versatile and efficient synthetic procedure for the grandisol pheromone library has been established. The key feature of our synthesis involves a versatile and highly regioselective Pd(0)-catalyzed intramolecular allylic alkylation for the key cyclobutane skeleton of grandisol. In this connection, the concise synthesis of (±)-grandisol as well as mechanism study of Pd(0)-catalyzed regioselective cyclization as a key reaction have also been accomplished.
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Han, Y.T., Kim, NJ., Jung, JW. et al. A versatile synthetic approach to grandisol monoterpene pheromone. Arch. Pharm. Res. 34, 1437–1442 (2011). https://doi.org/10.1007/s12272-011-0904-7
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DOI: https://doi.org/10.1007/s12272-011-0904-7