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An In-line, High Sensitivity, Non-contact Sensor for the Detection of Initiation of Sticking

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Abstract

Purpose

In this paper, the development and testing of a laser sensor to detect initiation of sticking are discussed.

Method

The basic working principle of the device involves a laser source aimed at the punch tip, and a photosensor measuring the intensity of the reflected beam.

Results

The initial results show that the laser sensor can detect the accumulation of material on a flat punch tip and has the potential to be used as a real-time monitoring device during tablet manufacturing operations.

Conclusions

This work demonstrated that the laser sensor can characterize initiation of sticking with high sensitivity without the need to interrupt the compaction process as typically done with other sticking characterization techniques.

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Acknowledgements

The authors would like to thank GlaxoSmithKline for their financial support and access to instrumentation.

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Authors and Affiliations

  1. Drug Product Design and Development, GlaxoSmithKline, 1250 S Collegeville Rd, Collegeville, PA, 19426, USA

    James Thomas

  2. Material Science and Engineering, Drexel University, 3141 Chestnut St, Philadelphia, PA, 19104, USA

    James Thomas & Antonios Zavaliangos

Authors
  1. James Thomas
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  2. Antonios Zavaliangos
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Correspondence to James Thomas.

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Thomas, J., Zavaliangos, A. An In-line, High Sensitivity, Non-contact Sensor for the Detection of Initiation of Sticking. J Pharm Innov 15, 66–72 (2020). https://doi.org/10.1007/s12247-018-9367-4

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  • DOI: https://doi.org/10.1007/s12247-018-9367-4

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