Abstract
A selection of tert-butylhydroperoxide (tBOOH)-tolerant Candida albicans mutants showed increased tolerances to 19 different stress conditions. These mutants are characterized by a constitutively upregulated antioxidative defense system and, therefore, adaptation to oxidative stress may play an important role in gaining general stress tolerance in C. albicans. Although C. albicans cells may undergo morphological transitions under various stress treatments, this ability shows considerable stress-specific and strain-specific variability and, hence, it is independent of mounting stress cross protections.
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Acknowledgments
The authors are indebted to Prof P. Sudbery (University of Sheffield) for his generous help in the identification of the morphological forms. The authors thank Mr. Imre Pócsi (University of Debrecen) for his valuable contribution to the growth inhibitory assays and Misters László Papp, Máté Szarka, and Imre Boczonádi (University of Debrecen) for their kind help in the microscopic techniques. This project was supported financially by the TÁMOP 4.2.1./B-09/1/KONV-2010-0007, the TÁMOP-4.2.2/B-10/1-2010-002, and the TÁMOP-4.2.2/B-10/1-2010-0024 projects, which are cofinanced by the European Union and the European Social Fund.
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Jakab, Á., Antal, K., Kiss, Á. et al. Increased oxidative stress tolerance results in general stress tolerance in Candida albicans independently of stress-elicited morphological transitions. Folia Microbiol 59, 333–340 (2014). https://doi.org/10.1007/s12223-014-0305-7
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DOI: https://doi.org/10.1007/s12223-014-0305-7