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Chitosan-Polyacrylic Acid Hybrid Nanoparticles as Novel Tissue Adhesive: Synthesis and Characterization

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Abstract

Chitosan (Cs)-poly acrylic acid (PAA) complex nanoparticles well dispersed and stable in aqueous solution was prepared by free radical polymerization of acrylic acid monomers (AA) in the presence of chitosan (Cs). Different concentrations of Cs and AA was cross-linked to form scalable hybrid nanoparticles (HNP). The physicochemical characterization of nanopolymers was investigated using FTIR, dynamic light scattering (DLS) and scanning electron microscopy (SEM). Infrared spectroscopy and electronic microscopy analysis results showed the preparation of Cs-PAA hybrid nanoparticles due to the formation of polyelectrolyte complexes and their spherical shape, respectively. The average particle size obtained under 180 nm for all samples obtained by using DLS analysis. A dhesion strength for the samples with a ratio of Cs/AA 1: 1 and 0.2: 1 was 50 to 120 kPa and 120 to 230 kPa, respectively. Cytotoxicity assay (MTT) showed that cell activity for concentrations X/5 and X/10 was over 7 5 %, demonstrating the sample extracts have suitable cytocompatibility. In addition, hemolytic assay of the samples represents below 0.5 % (according to the standard) in damage extend to red blood cells. Furthermore, prepared tissue adhesive based on Cs-PAA hybrid NPs in terms of adhesion strength was competitive with commercial samples as well as satisfactory results in terms of biocompatibility and blood compatibility were achieved in comparison with commercial available adhesives based on cyanoacrylate.

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Authors and Affiliations

  1. Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran

    Javad Saberi

  2. Department of Biomedical Engineering, Meybod University, Meybod, 89619-55133, Iran

    Mojtaba Ansari

  3. Department of Life Science Engineering (LSE), Faculty of New Sciences and Technologies (FNST), University of Tehran, Tehran, 14174, Iran

    Bahman Ebrahimi Hoseinzadeh

  4. Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, 1417466191, Iran

    Soheila Salahshour Kordestani

  5. Nanobioengineering Division, Nanotechnology Department, School of New Technologies, Iran University of Science and Technology, Tehran, 16846-13114, Iran

    Seyed Morteza Naghib

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  1. Javad Saberi
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  2. Mojtaba Ansari
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  3. Bahman Ebrahimi Hoseinzadeh
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  4. Soheila Salahshour Kordestani
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  5. Seyed Morteza Naghib
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Correspondence to Mojtaba Ansari.

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Saberi, J., Ansari, M., Ebrahimi Hoseinzadeh, B. et al. Chitosan-Polyacrylic Acid Hybrid Nanoparticles as Novel Tissue Adhesive: Synthesis and Characterization. Fibers Polym 19, 2458–2464 (2018). https://doi.org/10.1007/s12221-018-8762-2

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  • DOI: https://doi.org/10.1007/s12221-018-8762-2

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