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Evaluation of attenuation correction method for head holder in brain perfusion single-photon emission computed tomography

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Abstract

Head holder attenuation affects brain perfusion single-photon emission computed tomography (SPECT) image quality. Here, we proposed a head holder-attenuation correction (AC) method using attenuation coefficient maps calculated by Chang’s method from CT images. Then, we evaluated the effectiveness of the head holder-AC method by numerical phantom and clinical cerebral perfusion SPECT studies. In the numerical phantom, the posterior counts were 10.7% lower than the anterior counts without head holder-AC method. However, by performing head holder-AC, the posterior count recovered by approximately 6.8%, approaching the true value. In the clinical study, the normalized count ratio was significantly increased by performing the head holder-AC method in the posterior-middle cerebral artery, posterior cerebral artery and cerebellum regions. There were no significant increases in other regions. The head holder-AC method can correct the counts attenuated by the head holder.

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Acknowledgements

We would like to thank Editage (www.editage.com) for the English language editing.

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Authors and Affiliations

  1. Division of Radiological Technology, Okayama University Hospital, 2-5-1 Shikatacho, Kitaku, Okayama, 700-8558, Japan

    Masahiro Nakashima

  2. Canon Medical Systems Corporation, 1385 Shimoishigami, Otawara-Shi, Tochigi, 324-8550, Japan

    Yuta Yamazaki

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  1. Masahiro Nakashima
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  2. Yuta Yamazaki
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Correspondence to Masahiro Nakashima.

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Conflict of interest

Yuta Yamazaki is an employee of Canon Medical Systems Corporation. Nakashima received software created in the interface definition language from Canon Medical Systems Corporation.

Ethics approval

All the procedures performed in this study, which involved human participants, were in accordance with the ethical standards of the institutional and/or national research committee and the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by the Bioethics Committee of Okayama University Hospital (No. 2104–015).

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Nakashima, M., Yamazaki, Y. Evaluation of attenuation correction method for head holder in brain perfusion single-photon emission computed tomography. Radiol Phys Technol 17, 322–328 (2024). https://doi.org/10.1007/s12194-024-00778-x

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  • DOI: https://doi.org/10.1007/s12194-024-00778-x

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