Abstract
A 29-year-old female patient who was being followed up for differentiated papillary thyroid carcinoma was referred to us for exploration of any possible metastasis since her serum thyroglobulin levels were high. The patient underwent an F-18 fluorodeoxyglucose positron emission tomography study, and a pathologically increased FDG uptake at the left lower abdomen was detected corresponding to a solid, cystic lesion on CT images. The patient had a history of primary amenorrhea and, together with the magnetic resonance imaging findings of absent uterus, short and blind end vagina, a diagnosis of androgen insensitivity syndrome was made. The patient underwent laparoscopic left pelvic mass resection, and the histopathology of the lesion revealed Sertoli–Leydig cell tumor.
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Morris JM. The syndrome of testicular feminization in male pseudohermaphrodites. Am J Obstet Gynecol. 1953;65:1192.
Bowen P, Lee CS, Migeon CJ, Kaplan NM, Whalley PJ, Mckusik VA, et al. Hereditary male pseudohermaphroditism with hypogonadism, hypospadias and gynecomastia: Reifenstein’s syndrome. Ann Int Med. 1965;62:252.
Goldberg MB, Maxwell AF. Male pseudohermaphroditism proved by surgical exploration and microscopic examination. A case report with speculations concerning pathogenesis. J Clin Endocrinol. 1948;8:367.
Hughes I, Deeb A. Androgen resistance. Best Pract Res Clin Endocrinol Metab. 2006;20:577.
Grumbach MN. Disorders of sex differentiation. In: Larsen PR, editor. Williams textbook of endocrinology. Philadelphia: Saunders; 2003. p. 842–1002.
Bangsboll S, Qvist I, Lebech PE, Lewinsky MS. Testicular feminization syndrome and associated gonadal tumors in Denmark. Acta Obstet Gynecol Scand. 1992;71:63.
Boehmer AL, Brinkmann O, Brüggenwirth H. Genotype versus phenotype in families with androgen insensitivity syndrome. J Clin Endocrinol Metab. 2001;86:4151.
Oakes MB, Eyvazzadeh AD, Quint E, Smith YR. Complete androgen insensitivity syndrome—a review. J Pediatr Adolesc Gynecol. 2008;21(6):305–10.
Baksu A, Kabukcuoglu F, Baksu B, Goker N. Bilateral Sertoli cell adenoma and serous cyst in a patient with androgen insensitivity syndrome. Eur J Obstet Gynecol Reprod Biol. 2004;114(1):104–7.
Iwamoto I, Yanazume S, Fujino T, Yoshioka T, Douchi T. Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome. Gynecol Oncol. 2005;96(3):870–2.
Nguyen BD. PET imaging of Sertoli cell tumor in androgen insensitivity syndrome. Clin Nucl Med. 2003;28(9):743–5.
Hannema SE, Scott IS, Rajpert-De Meyts E, Skakkebaek NE, Coleman N, Hughes IA. Testicular development in the complete androgen insensitivity syndrome. J Pathol. 2006;208(4):518–27.
Rutgers JL, Scully RE. The androgen insensitivity syndrome (testicular feminization): a clinicopathologic study of 43 cases. Int J Gynecol Pathol. 1991;10(2):126–44.
Ayhan A, Tuncer ZS, Hakverdi AU, Yuce K. Sertoli–Leydig cell tumors of the ovary: a clinicopathologic study of 10 cases. Eur J Gynaecol Oncol. 1995;17:75–8.
Choong CS, Fuller PJ, Chu S, Jeske Y, Bowling F, Brown R, et al. Sertoli–Leydig cell tumor of the ovary: a rare cause of precocious puberty in a 12-month-old infant. J Clin Endocrinol Metab. 2002;87:49–56.
Jarzabek K, Philibert P, Koda M, Sulkowski S, Kotula-Balak M, Bilinska B, et al. Primary amenorrhea in a young Polish woman with complete androgen insensitivity syndrome and Sertoli–Leydig cell tumor: identification of a new androgen receptor gene mutation and evidence of aromatase hyperactivity and apoptosis dysregulation within the tumor. Gynecol Endocrinol. 2007;23(9):499–504.
Young RH, Scully RE. Ovarian Sertoli–Leydig cell tumors: a clinicopathological analysis of 207 cases. Am J Surg Pathol. 1985;9:543–69.
Cremerius U, Effert PJ, Adam G, Sabri O, Zimmy M, Wagenknecht G, et al. FDG PET for detection and therapy control of metastatic germ cell tumor. J Nucl Med. 1998;39(5):815–22.
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Özülker, T., Özpaçacı, T., Özülker, F. et al. Incidental detection of Sertoli–Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome. Ann Nucl Med 24, 35–39 (2010). https://doi.org/10.1007/s12149-009-0321-x
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DOI: https://doi.org/10.1007/s12149-009-0321-x