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CD30 Expression in Oral and Oropharyngeal Diffuse Large B Cell Lymphoma, not Otherwise Specified

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Abstract

Diffuse large B cell lymphoma, not otherwise specified (DLBCL, NOS) is the most frequent non-Hodgkin lymphoma subtype. This aggressive neoplasm may variably express the CD30 protein, which may be used as a therapeutic target for this tumor. However, CD30 expression in DLBCL NOS arising from the oral cavity and the oropharynx has not been investigated. Therefore, this study aims to determine the frequency of CD30 expression and its prognostic significance for patients affected by oral/oropharyngeal DLBCL NOS. Fifty cases were retrieved from pathology files and submitted to immunohistochemistry against CD30. Reactivity was accessed by two oral pathologists using two cut-off values (> 0% and > 20% of tumor cells) to determine positivity in each case. Clinical data were obtained from the patients’ medical files to investigate the prognostic potential of the protein. Seven high-grade B cell lymphomas and two EBV-positive DLBCL NOS were identified. We found one CD30-positive case in each of these two groups of lymphomas. Among the remaining 41 DLBCL NOS, other four cases (three in the oral cavity and one in the oropharynx) were positive for CD30, but only two expressed the protein in > 20% of tumor cells, both in the oral cavity. Survival analysis demonstrated that CD30-positive cases had a higher five-year overall survival rate (75%) than CD30-negative cases (32.3%), although a statistically significant result was not achieved (p = 0.19). Only a minor subset of oral and oropharyngeal DLBCL NOS express CD30 and these patients seems to have a higher survival rate.

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Funding

This study was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/Brazil, Finance Code 001), the São Paulo State Research Foundation (FAPESP/Brazil) (FAPESP #17/14880–3), the Minas Gerais State Research Foundation (FAPEMIG #APQ-00623–18) and the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil #406452/2018–0). Manoela Domingues Martins, Pablo Agustin Vargas, Fábio Ramôa Pires and Felipe Paiva Fonseca are fellows of the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil).

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Author notes

  1. Ana Luísa Morais-Perdigão and Carla Isabelly Rodrigues-Fernandes have equally contributed to this work.

Authors and Affiliations

  1. Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901, Pampulha, Belo Horizonte, Brazil

    Ana Luísa Morais-Perdigão, Gabriela Ribeiro Araújo & Felipe Paiva Fonseca

  2. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil

    Carla Isabelly Rodrigues-Fernandes, Pablo Agustin Vargas & Felipe Paiva Fonseca

  3. Private Pathology Service, Natal, Rio Grande do Norte, Brazil

    Ciro Dantas Soares

  4. Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    Bruno Augusto Benevenuto de Andrade

  5. Department of Pathology, School of Dentistry, Federal University of Rio Grande Do Sul, Porto Alegre, Brazil

    Manoela Domingues Martins

  6. Department of Oral Biology and Oral Pathology, University of Pretoria, Pretoria, South Africa

    Pablo Agustin Vargas & Felipe Paiva Fonseca

  7. Service of Oral Pathology, João de Barros, Barreto University Hospital, Federal University of Pará, Belem, Brazil

    Hélder Antônio Rebelo Pontes & Rommel Mario Rodríguez Burbano

  8. Oral Pathology, Dental School, Rio de Janeiro State University, Rio de Janeiro, Brazil

    Fábio Ramôa Pires

Authors
  1. Ana Luísa Morais-Perdigão
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  2. Carla Isabelly Rodrigues-Fernandes
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  4. Ciro Dantas Soares
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  11. Felipe Paiva Fonseca
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Contributions

Study concepts: Felipe Paiva Fonseca; Study design: Felipe Paiva Fonseca and Ciro Dantas Soares; Data acquisition: Ana Luísa Morais-Perdigão, Carla Isabelly Rodrigues-Fernandes, Gabriela Ribeiro Araújo, Bruno Augusto Benevenuto de Andrade; Quality control of data and algorithms: Carla Isabelly Rodrigues-Fernandes, Manoela Domingues Martins; Data analysis and interpretation: Felipe Paiva Fonseca, Ana Luísa Morais-Perdigão, Carla Isabelly Rodrigues-Fernandes, Fábio Ramôa Pires; Statistical analysis:: Felipe Paiva Fonseca, Ana Luísa Morais-Perdigão, Rommel Mario Rodríguez Burbano; Manuscript preparation: Ana Luísa Morais-Perdigão; Manuscript editing: Ana Luísa Morais-Perdigão, Hélder Antônio Rebelo Pontes; Manuscript review: Felipe Paiva Fonseca, Carla Isabelly Rodrigues-Fernandes, Pablo Agustin Vargas.

Corresponding author

Correspondence to Felipe Paiva Fonseca.

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The authors have no conflicts of interest to declare that are relevant to the content of this article.

Ethical Approval

This study was approved by the Ethical Committee of the Piracicaba Dental School, University of Campinas, Piracicaba, Brazil (process no. 44647421.1.0000.5418). All procedures followed the ethical standards of the Helsinki Declaration of 1975, as revised in 2008.

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Informed consent was obtained from the individual participants included in the study.

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Patients signed informed consent regarding publishing their data. No clinical photograph is used in this publication.

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Morais-Perdigão, A.L., Rodrigues-Fernandes, C.I., Araújo, G.R. et al. CD30 Expression in Oral and Oropharyngeal Diffuse Large B Cell Lymphoma, not Otherwise Specified. Head and Neck Pathol 16, 476–485 (2022). https://doi.org/10.1007/s12105-021-01387-5

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  • DOI: https://doi.org/10.1007/s12105-021-01387-5

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