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Human Papillomavirus (HPV)-Related Carcinoma of the Oropharynx with Squamous Cell and Adenoid Cystic Carcinoma-Like Features: Report of a Case

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Abstract

We describe the heretofore unreported case of an HPV-related carcinoma of the palatine tonsil with distinct areas of squamous cell- and adenoid cystic carcinoma-like differentiation in a 54-year old patient. The morphological, immunophenotypic and molecular findings of the tumor are illustrated. We discuss the parallels between the tumor and HPV-related multiphenotypic sinonasal carcinoma (HMSC) which is well-known to exhibit adenoid cystic carcinoma-like features. A review of the literature of high-risk HPV-associated non-squamous carcinomas of the oropharynx is presented.

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Authors and Affiliations

  1. Department of Pathology, University of Iowa Hospitals and Clinics, 5239D 200 Hawkins Drive, Iowa City, IA, 52242, USA

    Christina K. Hodgson, Chris S. Jensen, Robert A. Robinson & Anand Rajan K.D.

  2. Department of Otolaryngology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA

    Rodrigo Bayon

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Contributions

All authors attest that they meet the current ICMJE criteria for Authorship.All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by CKH, RAR and ARKD. The first draft of the manuscript was written by ARKD and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Anand Rajan K.D..

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This report does not contain any personal identifying information. The University of Iowa Human Subjects Office determined that the study did not meet regulatory definition of human subjects’ research as it is a case report on a single case and exempted review by the IRB.

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Hodgson, C.K., Bayon, R., Jensen, C.S. et al. Human Papillomavirus (HPV)-Related Carcinoma of the Oropharynx with Squamous Cell and Adenoid Cystic Carcinoma-Like Features: Report of a Case. Head and Neck Pathol 15, 1007–1016 (2021). https://doi.org/10.1007/s12105-020-01233-0

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  • DOI: https://doi.org/10.1007/s12105-020-01233-0

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