Skip to main content

Advertisement

SpringerLink
Log in

Expanding Awareness of the Distribution and Biologic Potential of Ectomesenchymal Chondromyxoid Tumor

  • Case Reports
  • Published:
Head and Neck Pathology Aims and scope Submit manuscript

Abstract

Ectomesenchymal chondromyxoid tumor is a rare neoplasm of uncertain histogenesis that typically occurs in the anterior dorsal tongue. Recent reports in the literature have described rare examples of gingival, palatal and tonsillar lesions. Histologically, ectomesenchymal chondromyxoid tumors are typically well-circumscribed, lacking overtly aggressive features. Herein we report a tumor arising in the right mandible that is morphologically and molecularly consistent with ectomesenchymal chondromyxoid tumor. This case furthers awareness of the extra-glossal distribution of this neoplasm; moreover, it suggests that a subset of these tumors have the potential for locally aggressive behaviour.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Smith BC, Ellis GL, Meis-Kindblom JM, Williams SB. Ectomesenchymal chondromyxoid tumor of the anterior tongue. Nineteen cases of a new clinicopathologic entity. Am J Surg Pathol. 1995;19(5):519–30.

    Article  CAS  Google Scholar 

  2. Dickson BC, Antonescu CR, Argyris PP, et al. Ectomesenchymal chondromyxoid tumor: a neoplasm characterized by recurrent RREB1-MKL2 fusions. Am J Surg Pathol. 2018;42(10):1297–305.

    Article  Google Scholar 

  3. Truschnegg A, Acham S, Kqiku L, Jakse N, Beham A. Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report. Int J Oral Sci. 2018;10(1):4.

    Article  Google Scholar 

  4. Gouvêa AF, Díaz KP, Léon JE, Vargas PA, de Almeida OP, Lopes MA. Nodular lesion in the anterior hard palate. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(2):154–9.

    Article  Google Scholar 

  5. Nigam S, Dhingra KK, Gulati A. Ectomesenchymal chondromyxoid tumor of the hard palate—a case report. J Oral Pathol Med. 2006;35(2):126–8.

    Article  Google Scholar 

  6. Stecco A, Quagliozzi M, Pino M, et al. An unusual case of ectomesenchymal chondromyxoid tumour of the left tonsillar bed: imaging and histopathologic features. BJR Case Rep. 2016;2(3):20150183.

    PubMed  PubMed Central  Google Scholar 

  7. Ide F. Chondromyxoid tumor of palate. J Oral Pathol Med. 2006;35(8):523–4.

    Article  Google Scholar 

  8. Portnof JE, Friedman JM, Reich R, Freedman PD, Behrman DA. Oral ectomesenchymal chondromyxoid tumor: case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endocrinol. 2009;108(4):e20-4.

    Article  Google Scholar 

  9. Aldojain A, Jaradat J, Summersgill K, Bilodeau EA. Ectomesenchymal chondromyxoid tumor: a series of seven cases and review of the literature. Head Neck Pathol. 2015;9(3):315–22.

    Article  Google Scholar 

  10. Sengul D, Sengul I, Ozdol MU, Astarci MH, Ustun H. Ectomesenchymal chondromyxoid tumor of the anterior tongue: a rare case. Kaohsiung J Med Sci. 2011;27(5):203–5.

    Article  Google Scholar 

  11. Seo SH, Shin DH, Kang HJ, et al. Reticulated myxoid tumor of the tongue: 2 cases supporting an expanded clinical and immunophenotypic spectrum of ectomesenchymal chondromyxoid tumor of the tongue. Am J Dermatopathol. 2010;32(7):660–4.

    Article  Google Scholar 

  12. de Visscher JG, Kibbelaar RE, van der Waal I. Ectomesenchymal chondromyxoid tumor of the anterior tongue. Report of two cases. Oral Oncol. 2003;39(1):83–6.

    Article  Google Scholar 

  13. Argyris PP, Bilodeau EA, Yancoskie AE, et al. A subset of ectomesenchymal chondromyxoid tumours of the tongue show EWSR1 rearrangements and are genetically linked to soft tissue myoepithelial neoplasms: a study of 11 cases. Histopathology. 2016;69(4):607–13.

    Article  Google Scholar 

  14. Siegfried A, Romary C, Escudié F, et al. RREB1-MKL2 fusion in biphenotypic “oropharyngeal” sarcoma: new entity or part of the spectrum of biphenotypic sinonasal sarcomas? Genes Chromosomes Cancer. 2018;57(4):203–10.

    Article  CAS  Google Scholar 

  15. Makise N, Mori T, Kobayashi H, et al. Mesenchymal tumors with RREB1-MRTFB fusion involving the mediastinum: extra-glossal ectomesenchymal chondromyxoid tumors? Histopathology. 2020. https://doi.org/10.1111/his.14080.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Dentistry, University of Toronto, Toronto, ON, Canada

    Justin Bubola

  2. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada

    Brendan C. Dickson

  3. Department of Dental and Maxillofacial Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    Klieb Hagen & Nick Blanas

  4. Department of Pathology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    Klieb Hagen & Tra Truong

  5. Laboratory Medicine Program, University Health Network, Toronto, ON, Canada

    Ilan Weinreb

  6. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

    Ilan Weinreb & Brendan C. Dickson

Authors
  1. Justin Bubola
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Klieb Hagen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nick Blanas
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ilan Weinreb
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Brendan C. Dickson
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tra Truong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tra Truong.

Ethics declarations

Conflict of interest

The authors declare that there is no conflict of interest to disclose

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 14 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bubola, J., Hagen, K., Blanas, N. et al. Expanding Awareness of the Distribution and Biologic Potential of Ectomesenchymal Chondromyxoid Tumor. Head and Neck Pathol 15, 319–322 (2021). https://doi.org/10.1007/s12105-020-01169-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12105-020-01169-5

Keywords

Search

Navigation