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Incidence and survival of central nervous system tumors in childhood and adolescence in Girona (Spain) 1990–2013: national and international comparisons

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Abstract

Introduction

Pediatric central nervous system tumors are one of the most frequent types of neoplasms in children but epidemiological data on these tumors have been sparsely reported in the medical literature.

Materials and methods

We analyze the epidemiology of this type of tumors performing a retrospective population-based study in pediatrics and adolescent age in the population of Girona and compare them with series from Spain, Europe and worldwide. Cases were registered using the International Classification of Disease for Oncology, third edition and grouping according the International Classification of Childhood Cancer, third edition (ICCC-3).

Results

For all the histologies and the whole population between 0 and 19 years old, ASRw was 41.8 cases per million person-years. In children population, meaning under 14 years old, we found 104 cases with ASRw of 45.6. Males were the most affected by CNS tumors with a 1.2 sex ratio between 0 and 14 years old, and 1.1 between 0 and 19 years old. The analysis of trends in incidence did not find any statistically significant increase or decrease. Five-year observed survival was 68%, both for patients under 19 and 14 years of age.

Conclusions

The incidence in our area was among the highest in Spain and worldwide, while survival was comparable to others reported.

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Fig. 1

Source: IICC-3 web (Available form: http://iicc.iarc.fr/results/)

Fig. 2

Source: data form Girona cancer registry

Fig. 3

Source: IICC-3 web (Available form: http://iicc.iarc.fr/results/)

Fig. 4

Source: IICC-3 web (Available form: http://iicc.iarc.fr/results/)

Fig. 5

Source: data form Glrona cancer registry

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Abbreviations

ACCIS:

Automated Childhood Cancer Information System

ASRe:

Age-standardized rate (using European Standard Population)

ASRw:

Age-standardized rate (using World Standard Population)

CI:

Confidence interval

CNS:

Central nervous system

DCO:

Death certificate only

EAPC:

Estimated annual percentage of change

GCR:

Girona Cancer Registry

IARC:

International Agency for Research on Cancer

ICD-O-3:

International Classification of Disease for Oncology, third edition

ICCC-3:

International Classification of Childhood Cancer, third edition

IICC-3:

International Incidence of Childhood Cancer

MV:

Microscopically verified

NOS:

Not otherwise specified (unspecified tumors)

OS:

Observed survival

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Acknowledgements

We thank Katie Linder for the review of English grammar.

Author information

Authors and Affiliations

  1. Descriptive Epidemiology, Genetics and Cancer Prevention Group, Biomedical Research Institute (IDIBGI), Girona, Spain

    S. Rivas-Vilela, J. Rubió-Casadevall, A. Fàbrega-Ribas, L. Vilardell & R. Marcos-Gragera

  2. Medical Oncology Department, Catalan Institute of Oncology, Girona, Spain

    J. Rubió-Casadevall

  3. School of Medicine, University of Girona (UdG), Girona, Spain

    J. Rubió-Casadevall, C. Joly-Torta & R. Marcos-Gragera

  4. Department of Neuro-surgery, University Hospital Josep Trueta, Girona, Catalan Institute of Health, Girona, Spain

    C. Joly-Torta

  5. Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health Government of Catalonia, Catalan Institute of Oncology, Girona, Spain

    L. Vilardell & R. Marcos-Gragera

  6. CIBER Epidemiología y Salud Pública, Madrid, Spain

    R. Marcos-Gragera

Authors
  1. S. Rivas-Vilela
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  2. J. Rubió-Casadevall
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  3. A. Fàbrega-Ribas
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  4. C. Joly-Torta
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  5. L. Vilardell
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  6. R. Marcos-Gragera
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Corresponding author

Correspondence to R. Marcos-Gragera.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

The Epidemiology Unit and Girona Cancer Registry (GCR) is a statistical unit part of the Pla estadístic de Catalunya approved to produce official estiamtes of cancer incidence and mortality. The GCR studies are except of inform consent as they involve large datasets, are retrospective and observational, characteristics that make consent impractical to collect. Nonetheless, security measures are taken accordingly in order to protect patient confidentiality.

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Rivas-Vilela, S., Rubió-Casadevall, J., Fàbrega-Ribas, A. et al. Incidence and survival of central nervous system tumors in childhood and adolescence in Girona (Spain) 1990–2013: national and international comparisons. Clin Transl Oncol 21, 1177–1185 (2019). https://doi.org/10.1007/s12094-019-02043-9

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  • DOI: https://doi.org/10.1007/s12094-019-02043-9

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