Skip to main content
SpringerLink
Log in

Giant Pleomorphic Adenomas of Parotid Gland: a Case Series

  • Original Article
  • Published:
Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

The parotid gland is the largest salivary gland in the body. Pleomorphic adenomas (PA) are most common benign tumors of parotid gland. If left untreated, they can gradually attain the size which can weigh several kilograms. This paper highlights a case series of 15 cases diagnosed as giant pleomorphic adenoma arising in the parotid gland along with their management. A hospital based, observational study of 15 patients of PA of the parotid gland, > 10 cm in its widest dimension considered as giant, done at tertiary care ENT hospital over period of 9 years. The age of the patients ranged from 30 to 81 years with mean age 50.33 ± 15.30 years. There were 5(33.33%) males and 10(66.67%) females. The time duration of having tumor ranged from 5 to 20 years with mean duration of 10.4 ± 4.17 years and the largest tumor was 25 cm in its largest diameter. Mean weight of tumors was 2.72 ± 0.52 kg. One out of fifteen cases was detected as malignant in nature. All cases were treated by surgical excision without any complications. Pleomorphic adenoma of parotid gland can assume a giant proportion when timely surgical intervention is not done. We can build up confidence and hope for life in patients after complete surgical excision of giant PA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Spiro RM, Koss LG, Hajdu SI (1973) Tumors of minor salivary origin. A clinicopathologic study of 492 cases 31:117–129

  2. Phillips DE, Jones AS (1994) Reliability of clinical examination in the diagnosis of parotid tumors. JR Coll Surg Edinb 392:100–102

    Google Scholar 

  3. Martinelli M, Martini F, Rinaldi E et al (2002) Simian virus 40 sequences and expression of the viral large T antigen oncoprotein in human pleomorphic adenomas of parotid glands. Am J Pathol 161(4):1127–1133

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Buenting JE, Smith TL, Holmes DK (1998) Giant pleomorphic adenoma of the parotid gland: case report and review of the literature. Ear Nose Throat J 77(8):634, 637–638, 640

  5. Honda T, Yamamoto Y, Isago T, Nakazawa H, Nozaki M, Hirayama T (2005) Giant pleomorphic adenoma of the parotid gland with malignant transformation. Ann Plast Surg 55(5):524–527

    Article  CAS  PubMed  Google Scholar 

  6. Schultz-Coulon HJ (1989) Pleomorphic giant adenomas of the parotid gland. Laryngorhinootologie 68:445–449

    Article  CAS  PubMed  Google Scholar 

  7. Sergi B, Limongelli A, Scarano E, Fetoni AR, Paludetti G (2008) Giant deep lobe parotid gland pleomorphic adenoma involving the parapharyngeal space—report of three cases and review of the diagnostic and therapeutic approaches. Acta Otorhinolaryngol Ital 28:261–265

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Dalati T, Hussein MR (2009) Juvenile pleomorphic adenoma of the cheek: a case report and review of literature. Diagn Pathol 4(32):1–5

    Google Scholar 

  9. Guerriere CN, Goff JJ, Cummings GH, Auber AE (1999) An unusually large, solid tumor of the parotid gland. Ann Plast Surg 43(5):529–532

    Article  CAS  PubMed  Google Scholar 

  10. Omeje KU, Efunkoya AA, Amole OI, Osunde OD, Akhiwu IB, Agbara RC (2016) Giant pleomorphic adenoma of major salivary glands: a review of ten cases. Afr J Med Health Sci 15:92–96

    Article  Google Scholar 

  11. Yamamoto Y et al (1994) Clinical signs and histology of carcinoma in pleomorphic adenoma. Otologia 87:1320–1324

    Google Scholar 

  12. Woods JE, Chong GC, Beahrs OH (1975) Experience with 1360 primary parotid tumors. Am J Surg 130:460–462

    Article  CAS  PubMed  Google Scholar 

  13. Oji C et al (1999) Late presentation of orofacial tumours. J Craniomaxillofac Surg 27:94–99

    Article  CAS  PubMed  Google Scholar 

  14. Olaitan AA, Arole G, Adekeye EO (2000) Socio-economic status of patients with ameloblastoma of the jaws. Natl Postgrad Med J 7:15

    Google Scholar 

  15. Laccourreye H, Laccourreye O, Cauchois R et al (1994) Total conservative parotidectomy for primary benign pleomorphic adenoma of the parotid gland: a 25-year experience with 229 patients. Laryngoscope 104:1487–1494

    Article  CAS  PubMed  Google Scholar 

  16. O’Brien CJ (2003) Current management of benign parotid tumors—the role of limited superficial parotidectomy. Head Neck 25:946–952

    Article  PubMed  Google Scholar 

  17. Takahama A Jr, Perez DEC, Magrin J, Almeida OP, Kowalski LP (2008) Giant pleomorphic adenoma of the parotid gland. Med Oral Patol Oral Cir Bucal 13(1):58–60

    Google Scholar 

  18. Sajid M, Rehman S, Misbah J (2015) Giant pleomorphic adenoma of the parotid gland. J Coll Physicians Surg Pak 25(Suppl 2):S110–S111

    PubMed  Google Scholar 

  19. Mendenhall WM, Mendenhall CM, Werning JW, Malyapa RS, Mendenhall NP (2008) Salivary gland pleomorphic adenoma. Am J Clin Oncol 31:95–99

    Article  PubMed  Google Scholar 

  20. Gleeson M, Cawson R (2008) Benign salivary gland tumors: Scott-Brown’s otolaryngology, head and neck surgery, vol 2, 7th edn. Hodder Arnold p, London, pp 2475–2492

    Google Scholar 

  21. Dawson AK, Orr JA (1985) Long-term results of local excision and radiotherapy in pleomorphic adenoma of the parotid. Int J Radiat Oncol Biol Phys 11:451–455

    Article  CAS  PubMed  Google Scholar 

  22. Hodge CW, Morris CG, Werning JW et al (2005) Role of radiotherapy for pleomorphic adenoma. Am J Clin Oncol 28:148–151

    Article  PubMed  Google Scholar 

  23. Blevins NH, Jackler RK, Kaplan MJ et al (1992) Facial paralysis due to benign parotid tumors. Arch Otolaryngol Head Neck Surg 118:427–430

    Article  CAS  PubMed  Google Scholar 

  24. Mehle ME, Krause DH, Wood BG, Benninger SM, Eliachar I, Levine HL et al (1993) Facial nerve morbidity following parotid surgery for benign disease. The cleveland clinic foundation experience. Laryngoscope 103:386–388

    Article  CAS  PubMed  Google Scholar 

  25. Bova R, Saylor A, Coman WB (2004) Parotidectomy: review of treatment and outcomes. ANZ J Surg 74:563–568

    Article  PubMed  Google Scholar 

  26. Silva SJ, Costa GT, Filho ACB, Faria PR, Loyola AM (2006) Metachronous bilateral pleomorphic adenoma of the parotid gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 101(3):333–338

    Article  Google Scholar 

  27. Maahs GS, Oppermann PO, Maahs LGP, Machado Filho G, Ronchi AD (2015) Parotid gland tumors: a retrospectivestudy of 154 patients. Braz J Otorhinolaryngol 81(3):301–306

    Article  PubMed  PubMed Central  Google Scholar 

  28. Mizui T, Ishimaru JI, Miyamoto K, Toida M (2000) Malignant transformation of a gigantic pleomorphic adenoma of the submandibular gland: a case report. J Oral Maxillofac Surg 58:1422–1424

    Article  CAS  PubMed  Google Scholar 

  29. Seifert G (1992) Histopathology of malignant salivary gland tumours. Eur J Cancer B Oral Oncol 28:49–56

    Article  Google Scholar 

  30. Boneu F, González-Lagunas J, Huguet P, Bassas C (1998) Massive malignant pleomorphic adenoma of the palate. J Oral Maxillofac Surg 56(1):91–96

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

None.

Author information

Authors and Affiliations

  1. Department of ENT and Head-Neck Surgery, SMS Medical College and Hospital, Jaipur, Rajasthan, India

    Yogendra Kumar Pareek

  2. SDH Kekri Government of Rajasthan, Ajmer Rajasthan, India

    Deendayal Gupta

  3. Department of ENT and Head-Neck Surgery, JLN Medical College and Hospital, Ajmer, Rajasthan, India

    Yogesh Aseri, Digvijay Singh Rawat, Bhuvenesh K. Singh & Praveen Chandra Verma

Authors
  1. Yogendra Kumar Pareek
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Deendayal Gupta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yogesh Aseri
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Digvijay Singh Rawat
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Bhuvenesh K. Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Praveen Chandra Verma
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yogendra Kumar Pareek.

Ethics declarations

Conflict of interest

The authors declare that they have no competing interests.

Ethical Approval

Ethical approval taken from institute ethics committee.

Informed Consent

Written and informed consent taken from all participants.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pareek, Y.K., Gupta, D., Aseri, Y. et al. Giant Pleomorphic Adenomas of Parotid Gland: a Case Series. Indian J Otolaryngol Head Neck Surg 74 (Suppl 2), 2008–2013 (2022). https://doi.org/10.1007/s12070-020-01968-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12070-020-01968-w

Keywords

Search

Navigation