Abstract
Pleomorphic adenoma is the most common type of all benign and malignant salivary gland tumors, involving more frequently the parotid gland. It is a benign painless and slowly growing tumor that if not treated, can continue growing to reach a massive size. We report a case of a giant pleomorphic adenoma of right parotid gland in a 25-year-old mentally challenged female, being the largest in size to be excised in Saudi Arabia in recorded literature measuring 18 × 17 × 11.5 cm and weighted 1.5 kg. Clinical examination revealed a giant mass on the right side of the face without any sign of facial nerve injury. The tumor was excised by superficial parotidectomy with preservation of the facial nerve. The patient was followed up to 1 year with good postoperative results and no signs of facial nerve injury or recurrence. Neglect, lack of information, or medical resources and fear of surgery allow such tumors to grow bigger in size which might complicate the treatment and increase the risk of malignant transformation.
Similar content being viewed by others
Abbreviations
- PA:
-
Pleomorphic adenoma
References
Ellis GL. Atlas of tumor pathology. Tumours of the salivary glands. Washington, DC: Armed Forces Institute of Pathology; 1995.
Califano J, Eisele DW. Benign salivary gland neoplasms. Otolaryngol Clin N Am. Oct. 1999;32(5):861–73.
Luna MA. Salivary glands. In: Pilch BZ, editor. Head and neck surgical pathology. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 284–349.
Buenting JE, Smith TL, Holmes DK. Giant pleomorphic adenoma of the parotid gland: case report and review of the literature. Ear Nose Throat J. Aug. 1998;77(8):634,637–8,640.
Sergi B, Limongelli A, Scarano E, Fetoni AR, Paludetti G. Giant deep lobe parotid gland pleomorphic adenoma involving the parapharyngeal space. Report of three cases and review of the diagnostic and therapeutic approaches. Acta Otorhinolaryngol Ital. Oct. 2008;28(5):261–5.
Morita N, Miyata K, Sakamoto T, Wada T. Pleomorphic adenoma in the parapharyngeal space: report of three cases. J Oral Maxillofac Surg. May 1995;53(5):605–10.
Pons Vicente O, Almendros Marques N, Berini Aytes L, Gay Escoda C. Minor salivary gland tumors: a clinicopathological study of 18 cases. Med Oral Patol Oral Cir Bucal. Sep. 2008;13(9):E582–8.
Aggarwal A, Singh R, Sheikh S, Pallagatti S, Singla I. Pleomorphic adenoma of minor salivary gland: a case report. RSBO Rev Sul-Brasileira Odontol. 2012;9:97–101.
Weng X, Guo F, Shen Z, Cheng B. Giant pleomorphic adenoma of the parotid gland with a history more than forty years without malignant transformation. Int J Clin Exp Med. 2018;11(2):1033–7.
Honda T, Yamamoto Y, Isago T, Nakazawa H, Nozaki M, Hirayama T. Giant pleomorphic adenoma of the parotid gland with malignant transformation. Ann Plast Surg. Nov. 2005;55(5):524–7.
de Silva MN, Kosgoda KMS, Tilakaratne WM, Murugadas P. A case of giant pleomorphic adenoma of the parotid gland. Oral Oncol Extra. 2004;40(3):43–5.
Takahama AJ, da Cruz Perez DE, Magrin J, de Almeida OP, Kowalski LP. Giant pleomorphic adenoma of the parotid gland. Med Oral Patol Oral Cir Bucal. 2008;13(1):E58–60.
Cetin MA, Ikinciogullari A, Saygi G, Hatipoglu HG, Koseoglu S, Dere H. Giant pleomorphic adenoma of the parotid gland. Kulak Burun Bogaz Ihtis Derg. 2012;22(2):116–8.
Jain S, Hasan S, Vyas N, Shah N, Dalal S. Pleomorphic adenoma of the parotid gland: report of a case with review of literature. Ethiop J Health Sci. Apr. 2015;25(2):189–94.
Tarsitano A, Pizzigallo A, Giorgini F, Marchetti C. Giant pleomorphic adenoma of the parotid gland: an unusual case presentation and literature review. Acta Otorhinolaryngol Ital. Oct. 2015;35(4):293–6.
Patankar S, Meshram M, Shewale V, Gokul S. Pleomorphic adenoma of parotid in a young patient. J Case Reports. 2013;3:142–7.
Thangaswamy V, Sivakumar A, Sivakumar A, Sivaraj S, Pugazhendi K, Thambiah L. Pleomorphic adenoma in an adolescent. J Pharm Bioallied Sci. 2012;4(Suppl 2):S435–6.
Spence J. Case of enormous deep-seated tumour of the face and neck, successfully removed by operation plates. Dublin J Med Sci. 1863;(36).
Short DW, Pullar P. Giant parotid tumours; with report of a case. J R Coll Surg Edinb. 1956;1(3):240–8.
Frylinck JR. An unusual tumour. S Afr Med J. 1956;30(20):479.
Schultz-Coulon HJ. Pleomorphic giant adenomas of the parotid gland. Laryngorhinootologie. 1989;68(8):445–9.
Sajid M, Rehman S, Misbah J. Giant pleomorphic adenoma of the parotid gland. J Coll Phys Surg Pak. Oct. 2015;25(Suppl 2):S110–1.
Auclair PL, Ellis GL. Atypical features in salivary gland mixed tumors: their relationship to malignant transformation. Mod Pathol. 1996;9(6):652–7.
Yamamoto Y. Clinical signs and histology of carcinoma in pleomorphicadenoma. Otologia. 1994;87:1320–4.
Eneroth CM, Zetterberg A. Malignancy in pleomorphic adenoma. A clinical and microspectrophotometric study. Acta Otolaryngol. 1974;77(6):426–32.
Snow G. The surgical approaches to the treatment of parotid pleomorphic adenomas. In: McGurk M, Renehan A, editors. Controversies in the management of salivary gland disease. Oxford: Oxford University Press; 2001. p. 57–66.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
The authors declare that they have no conflict of interest.
Ethical Approval
Ethical approval from Research Centre of King Saud Medical City was obtained under Reference Number H2RI-17-Dec18-01.
Informed Consent
Informed consent was obtained from the patient’s parents.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article is part of the Topical Collection on Surgery
Rights and permissions
About this article
Cite this article
Alnofaie, H., Alshammeri, T., Alturkistany, Y. et al. Giant Pleomorphic Adenoma of Parotid Gland in Saudi Arabia: a Rare Case Report. SN Compr. Clin. Med. 2, 1258–1263 (2020). https://doi.org/10.1007/s42399-020-00359-0
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s42399-020-00359-0