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Ablation, consolidation and radiotherapy for the management of metastatic lesions of the spine: impact on the quality of life in a mid-term clinical and diagnostic follow-up in a pilot study

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Abstract

Bone metastasis in the spine are lesions that are very challenging to manage because of pain, possible respiratory and neurological complications due to the closeness with the spinal cord. In fact, a fracture of a vertebra weakened by a pathological tissue can occur. In this paper, an experience of a single center in treating bone metastasis in the vertebral soma is reported (both fractured than with an increased risk of fracture) with a combined procedure of ablation, vertebroplasty and radiotherapy. This combined strategy aims to obtain an increased ability to treat the pathological tissue (ablation and radiotherapy) and a stabilization of the osteolytic lesion (vertebroplasty). We evaluated the outcome of this procedure in 12 lesions (in 11 patients) with a follow-up (from 6 to 48 months) with clinical and imaging data. Patients showed an immediate, rapid and persistent regression of the symptomatology in all lesions except two. Moreover, a stability of the disease in the bone segment treatment was reached. Even if this is a pilot study for the number of patients and the follow-up, we believe that this approach could be promising as these early results are. In specific clinical conditions and selected patients, this study seems to be possible to perform a curative approach.

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Acknowledgements

Authors wish to thank Angela Martella for translating the manuscript.

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Authors and Affiliations

  1. Department of Emergency and Interventional Radiology, San Salvatore Hospital, L’Aquila, Italy

    Francesco Arrigoni & Luigi Zugaro

  2. Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy

    Camilla de Cataldo, Federico Bruno, Pierpaolo Palumbo, Giovanni Luca Gravina, Antonio Barile & Carlo Masciocchi

  3. Department of Radiotherapy, San Salvatore Hospital, L’Aquila, Italy

    Mario Di Staso

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  1. Francesco Arrigoni
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Correspondence to Antonio Barile.

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Arrigoni, F., de Cataldo, C., Bruno, F. et al. Ablation, consolidation and radiotherapy for the management of metastatic lesions of the spine: impact on the quality of life in a mid-term clinical and diagnostic follow-up in a pilot study. Med Oncol 37, 53 (2020). https://doi.org/10.1007/s12032-020-01378-6

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