Skip to main content

Advertisement

SpringerLink
Log in

“One-Off” Complete Radiofrequency Ablation for Hepatocellular Carcinoma in a “High-Risk Location” Adjacent to the Major Bile Duct and Hepatic Blood Vessel

  • Original Paper
  • Published:
Cell Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

Radiofrequency ablation (RFA) is an effective, minimally invasive treatment option for unresectable hepatocellular carcinomas (HCCs) located in high-risk areas or for patients with poor hepatic functional reserve. However, for tumors adjacent to major bile ducts and hepatic blood vessels, complete ablation is difficult to achieve for fear of causing a postoperative bile leak, bilioma or bile duct stenosis. Therefore, RFA is often combined with multiple alcohol injections to eliminate residual tumor tissues in adjacent bile duct or blood vessels; however, the injections directly affect the efficacy and prognosis of RFA. This study reports three successful “one-off” cases of complete ablation of HCCs adjacent to major bile ducts and blood vessels in neighboring hepatic segments or hepatic lobes, highlighting both the efficacy and safety of RFA for HCC tumors in these high-risk locations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13
Fig. 14
Fig. 15

Similar content being viewed by others

References

  1. Ansari, D., & Andersson, R. (2012). Radiofrequency ablation or percutaneous ethanol injection for the treatment of liver tumors. World Journal of Gastroenterology, 18, 1003–1008.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Chen, M. S., Li, J. Q., Zheng, Y., Guo, R. P., Liang, H. H., Zhang, Y. Q., et al. (2006). A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma. Annals of Surgery, 243, 321–328.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Hildebrand, P., Kleemann, M., Roblick, U., Mirow, L., Birth, M., & Bruch, H. P. (2007). Laparoscopic radiofrequency ablation of unresectable hepatic malignancies: indication, limitation and results. Hepato-Gastroenterology, 54, 2069–2072.

    PubMed  Google Scholar 

  4. Hildebrand, P., Leibecke, T., Kleemann, M., Mirow, L., Birth, M., Bruch, H. P., et al. (2006). Influence of operator experience in radiofrequency ablation of malignant liver tumours on treatment outcome. European Journal of Surgical Oncology, 32, 430–434.

    Article  CAS  PubMed  Google Scholar 

  5. Liu, L. X., Jiang, H. C., & Piao, D. X. (2002). Radiofrequence ablation of liver cancers. World Journal of Gastroenterology, 8, 393–399.

    PubMed  Google Scholar 

  6. Kim, Y. S., Rhim, H., Lim, H. K., Choi, D., Lee, W. J., & Kim, S. H. (2007). Hepatic infarction after radiofrequency ablation of hepatocellular carcinoma with an internally cooled electrode. Journal of Vascular and Interventional Radiology, 18, 1126–1133.

    Article  PubMed  Google Scholar 

  7. Lee, J., Lee, J. M., Yoon, J. H., Lee, J. Y., Kim, S. H., Lee, J. E., et al. (2012). Percutaneous radiofrequency ablation with multiple electrodes for medium-sized hepatocellular carcinomas. Korean Journal of Radiology, 13, 34–43.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Song, I., Rhim, H., Lim, H. K., Kim, Y. S., & Choi, D. (2009). Percutaneous radiofrequency ablation of hepatocellular carcinoma abutting the diaphragm and gastrointestinal tracts with the use of artificial ascites: Safety and technical efficacy in 143 patients. European Radiology, 19, 2630–2640.

    Article  PubMed  Google Scholar 

  9. Soon, J. L., Jeyaraj, P. R., & Agasthian, T. (2008). Thoracic complications of radiofrequency ablation of recurrent hepatoma. Annals of the Academy of Medicine, Singapore, 37, 75–76.

    PubMed  Google Scholar 

  10. Azab, M., Zaki, S., El-Shetey, A. G., Abdel-Moty, M. F., Alnoomani, N. M., Gomaa, A. A., et al. (2011). Radiofrequency ablation combined with percutaneous ethanol injection in patients with hepatocellular carcinoma. Arab Journal of Gastroenterology, 12, 113–118.

    Article  CAS  PubMed  Google Scholar 

  11. Kamiya, J., Nagino, M., Uesaka, K., Sano, T., & Nimura, Y. (2003). Clinicoanatomical studies on the dorsal subsegmental bile duct of the right anterior superior segment of the human liver. Langenbeck’s Archives of Surgery/Deutsche Gesellschaft fur Chirurgie, 388, 107–111.

    PubMed  Google Scholar 

  12. Nimura, Y., Hayakawa, N., Kamiya, J., Kondo, S., Nagino, M., & Kanai, M. (1995). Hilar cholangiocarcinoma: Surgical anatomy and curative resection. Journal of Hepato-Biliary-Pancreatic Surgery, 2, 10.

    Article  Google Scholar 

  13. Chen, M. H., Yang, W., Yan, K., Zou, M. W., Solbiati, L., Liu, J. B., et al. (2004). Large liver tumors: Protocol for radiofrequency ablation and its clinical application in 110 patients—mathematic model, overlapping mode, and electrode placement process. Radiology, 232, 260–271.

    Article  PubMed  Google Scholar 

  14. de Baere, T., Rehim, M. A., Teriitheau, C., Deschamps, F., Lapeyre, M., Dromain, C., et al. (2006). Usefulness of guiding needles for radiofrequency ablative treatment of liver tumors. Cardiovascular and Interventional Radiology, 29, 650–654.

    Article  PubMed  Google Scholar 

  15. Dodd, G. D., I. I. I., Frank, M. S., Aribandi, M., Chopra, S., & Chintapalli, K. N. (2001). Radiofrequency thermal ablation: Computer analysis of the size of the thermal injury created by overlapping ablations. AJR. American Journal of Roentgenology, 177, 777–782.

    Article  PubMed  Google Scholar 

  16. Ni, Y., Mulier, S., Miao, Y., Michel, L., & Marchal, G. (2005). A review of the general aspects of radiofrequency ablation. Abdominal Imaging, 30, 381–400.

    Article  CAS  PubMed  Google Scholar 

  17. Germani, G., Pleguezuelo, M., Gurusamy, K., Meyer, T., Isgro, G., & Burroughs, A. K. (2010). Clinical outcomes of radiofrequency ablation, percutaneous alcohol and acetic acid injection for hepatocelullar carcinoma: A meta-analysis. Journal of Hepatology, 52, 380–388.

    Article  CAS  PubMed  Google Scholar 

  18. Huang, J., Li, T., Liu, N., Chen, M., He, Z., Ma, K., et al. (2011). Safety and reliability of hepatic radiofrequency ablation near the inferior vena cava: an experimental study. International Journal of Hyperthermia, 27, 116–123.

    Article  PubMed  Google Scholar 

  19. Nam, S. Y., Rhim, H., Kang, T. W., Lee, M. W., Kim, Y. S., Choi, D., et al. (2010). Percutaneous radiofrequency ablation for hepatic tumors abutting the diaphragm: Clinical assessment of the heat-sink effect of artificial ascites. AJR. American Journal of Roentgenology, 194, W227–W231.

    Article  PubMed  Google Scholar 

  20. Nishigaki, Y., Tomita, E., Hayashi, H., Suzuki, Y., Iritani, S., Kato, T., et al. (2013). Efficacy and safety of radiofrequency ablation for hepatocellular carcinoma in the caudate lobe of the liver. Hepatology Research, 43, 467–474.

    Article  CAS  PubMed  Google Scholar 

  21. Kai, J., Ming, S., Yang, L., Wen-Zhi, Z., Xiang-Qian, Z., Zhe, L., et al. (2013). Complete radio frequency ablation of hepatocellular carcinoma adjacent to the main bile duct and blood vessels between the first and the second hepatic portal. Cell Biochemistry and Biophysics, 66, 397–402.

    Article  PubMed  Google Scholar 

  22. Lu, D. S., Raman, S. S., Vodopich, D. J., Wang, M., Sayre, J., & Lassman, C. (2002). Effect of vessel size on creation of hepatic radiofrequency lesions in pigs: assessment of the “heat sink” effect. AJR. American Journal of Roentgenology, 178, 47–51.

    Article  PubMed  Google Scholar 

  23. Decadt, B., & Siriwardena, A. K. (2004). Radiofrequency ablation of liver tumours: Systematic review. Lancet Oncology, 5, 550–560.

    Article  PubMed  Google Scholar 

  24. Zhiqiang, H. (1962). Primary intrahepatic stones and its related problems. Chongqing: The Third Military College Press.

    Google Scholar 

  25. Jiang, K., Su, M., Zhang, W., Zhao, X., Wang, J., Dong, J., et al. (2013). Complete radiofrequency ablation of hepatolithiasis-associated cholangiocarcinoma and successful management of post-ablation bronchobiliary fistula. Cell Biochemistry Biophysics. doi:10.1007/s12013-013-9737-y.

    Google Scholar 

Download references

Acknowledgments

This work was supported by the National Key Technology R&D Program of China (No: 2012BI06B01), P. R. China.

Disclosure

The authors declare no conflict of interest

Author information

Authors and Affiliations

  1. Institute & Hospital of Hepatobiliary Surgery, Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China

    Kai Jiang, Wen-zhi Zhang, Yang Liu, Ming Su, Xiang-qian Zhao, Jia-hong Dong & Zhi-qiang Huang

Authors
  1. Kai Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wen-zhi Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yang Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ming Su
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiang-qian Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jia-hong Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zhi-qiang Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kai Jiang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jiang, K., Zhang, Wz., Liu, Y. et al. “One-Off” Complete Radiofrequency Ablation for Hepatocellular Carcinoma in a “High-Risk Location” Adjacent to the Major Bile Duct and Hepatic Blood Vessel. Cell Biochem Biophys 69, 605–617 (2014). https://doi.org/10.1007/s12013-014-9840-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12013-014-9840-8

Keywords

Search

Navigation