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The Association Between Dietary Magnesium Intake with Chronic Obstructive Pulmonary Disease and Lung Function in US Population: a Cross-sectional Study

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Abstract

Chronic obstructive pulmonary disease (COPD) is now considered among the top three contributors to mortality globally. There is limited understanding surrounding the contribution of magnesium to the progression of COPD. This survey aims to evaluate the connection between dietary magnesium intake and both lung function and COPD prevalence among the US population. The research comprised 4865 participants in the National Health and Nutrition Examination Survey (NHANES) program conducted from 2007 to 2012. To evaluate the association between dietary magnesium intake and lung function as well as COPD, the study conducted multiple regression analyses, stratified analyses, and smoothed curves. In this study, we explored the relationship between higher magnesium intake and higher FEV1 [β = 0.21 (95% CI 0.12, 0.30)] and FVC [β = 0.25 (95% CI 0.14, 0.36)] after accounting for all potential confounding factors. We demonstrated a relationship between increased magnesium intake and reduced odds of developing COPD [OR = 0.9993 (95% CI 0.9987, 1.0000)]. The results of stratified analyses further indicated that the relationship between magnesium intake and the risk of COPD is more pronounced in the 40–60 age group and males. The study demonstrated positive associations between the intake of dietary magnesium and both FEV1 and FVC. Additionally, an adverse relationship between magnesium intake and the prevalence of COPD was also observed, suggesting that supplementation with magnesium may be a practical approach to preventing and managing COPD.

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Data Availability

The datasets generated during and/or analyzed during the current study are available at https://www.cdc.gov/nchs/nhanes/about_nhanes.htm.

Abbreviations

COPD :

chronic obstructive pulmonary disease

NHANES :

National Health and Nutrition Examination Survey

FVC :

forced vital capacity

FEV 1 :

forced expiratory volume in the first second

BMI :

body mass index

OR :

odds ratio

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Authors and Affiliations

  1. Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

    Zhi-Feng Lin, Wan-Zhe Liao, Ze-Min Huang & Xu-Guang Guo

  2. Department of Clinical Medicine, The Second Clinical School of Guangzhou Medical University, Guangzhou, 511436, China

    Zhi-Feng Lin, Hua-Wei Lin, Xiao-Yue Liao & Yi-Yao Wang

  3. Department of Clinical Medicine, The Nanshan College of Guangzhou Medical University, Guangzhou, 511436, China

    Wan-Zhe Liao

  4. Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China

    Ze-Min Huang & Xu-Guang Guo

  5. Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, King Med School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 510000, China

    Xu-Guang Guo

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Contributions

Conceptualization, GXG and LZF; Data curation, LZF, LHW and LWZ; Writing – original draft, LZF, LHW, LXY and WYY; Writing – review & editing, HZM; Supervision, GXG. All authors contributed to the article and approved the final version of the manuscript.

Corresponding author

Correspondence to Xu-Guang Guo.

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Ethics Approval

All NHANES protocols utilized in this study received approval from the CDC’s National Center for Health Statistics Institutional Research Ethics Review Board.

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Informed consent was obtained from all individual participants included in the study.

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Not applicable.

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The authors have no relevant financial or non-financial interests to disclose.

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Lin, ZF., Lin, HW., Liao, WZ. et al. The Association Between Dietary Magnesium Intake with Chronic Obstructive Pulmonary Disease and Lung Function in US Population: a Cross-sectional Study. Biol Trace Elem Res 202, 3062–3072 (2024). https://doi.org/10.1007/s12011-024-04073-z

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