Skip to main content
SpringerLink
Log in

Association of Blood Selenium Level with Estimated Glomerular Filtration Rate in the Aging Population: a Cross-sectional Study

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

The relationship between blood selenium level and estimated glomerular filtration rate (eGFR) had been explored in previous studies. However, there are few studies about the correlation between blood selenium level and eGFR in the elderly population. This study was undertaken to investigate the relationship between blood selenium level and eGFR in the aged. The present study was a cross-sectional study and used the National Health and Nutrition Examination Survey (NHANES) 2011–2018 dataset. We investigated the association between blood selenium level and eGFR among participants aged 60 years or older. Totally, 4423 participants were enrolled, and the average age was 69.7 ± 6.9 years old. The means of blood selenium level and eGFR were 192.9 ± 29.5 ug/L and 74.1 ± 19.9 mL/min/1.73 m2, respectively. After adjusting potential confounders (age, gender, body mass index, ethnicity, marital status, education, family income to poverty ratio, smoking, hypertension, and diabetes mellitus), non-linear relationship was detected between blood selenium level and eGFR, whose inflection point was 202 ug/L. The effect sizes (β) and the confidence intervals on the left and right sides of inflection point were 0.07 (0.04 to 0.11) and 0.01 (− 0.02 to 0.04), respectively. In addition, subgroup analysis showed that blood selenium level was positively associated with eGFR, and the test for interactions was not statistically significant in various subgroups. In conclusion, the relationship between blood selenium level and eGFR is non-linear. Blood selenium level is positively related with eGFR when blood selenium level is less than 202 ug/L.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Data Availability

National Health and Nutrition Examination Survey (NHANES) data were available from the US Centers for Disease Control and Prevention at https://www.cdc.gov/nchs/nhanes/.

References

  1. Rayman MP (2012) Selenium and human health. Lancet 379(9822):1256–1268

    Article  CAS  PubMed  Google Scholar 

  2. Ju W, Ji M, Li X, Li Z, Wu G, Fu X et al (2018) Relationship between higher serum selenium level and adverse blood lipid profile. Clin Nutr 37(5):1512–1517

    Article  CAS  PubMed  Google Scholar 

  3. Ferguson LR, Karunasinghe N, Zhu S, Wang AH (2012) Selenium and its’ role in the maintenance of genomic stability. Mutat Res 733(1–2):100–110

    Article  CAS  PubMed  Google Scholar 

  4. Cai Z, Zhang J, Li H (2019) Selenium, aging and aging-related diseases. Aging Clin Exp Res 31(8):1035–1047

    Article  PubMed  Google Scholar 

  5. Aaseth J, Alexander J, Alehagen U, Tinkov A, Skalny A, Larsson A et al (2021) The aging kidney-as influenced by heavy metal exposure and selenium supplementation. Biomolecules 11(8):1078

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Barros MBA, Goldbaum M (2018) Challenges of aging in the context of social inequalities. Rev Saude Publica. 52(Suppl 2):1s

    Article  PubMed Central  Google Scholar 

  7. Guidi GC, Bellisola G, Bonadonna G, Manzato F, Ruzzenente O, Schiavon R et al (1990) Selenium supplementation increases renal glomerular filtration rate. J Trace Elem Electrolytes Health Dis 4(3):157–161

    CAS  PubMed  Google Scholar 

  8. Alehagen U, Aaseth J, Alexander J, Brismar K, Larsson A (2020) Selenium and coenzyme Q10 supplementation improves renal function in elderly deficient in selenium: observational results and results from a subgroup analysis of a prospective randomised double-blind placebo-controlled trial. Nutrients 12(12):3780

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Selvin E, Manzi J, Stevens LA, Van Lente F, Lacher DA, Levey AS et al (2007) Calibration of serum creatinine in the National Health and Nutrition Examination Surveys (NHANES) 1988–1994, 1999–2004. Am J Kidney Dis 50(6):918–926

    Article  CAS  PubMed  Google Scholar 

  10. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150(9):604–612

    Article  PubMed  PubMed Central  Google Scholar 

  11. Fadeyev K, Nagao-Sato S, Reicks M (2021) Nutrient and food group intakes among U.S. children (2–5 Years) differ by family income to poverty ratio, NHANES 2011–2018. Int J Environ Res Public Health. 18(22):11938

    Article  PubMed  PubMed Central  Google Scholar 

  12. Muntner P, Hardy ST, Fine LJ, Jaeger BC, Wozniak G, Levitan EB et al (2020) Trends in blood pressure control among US adults with hypertension, 1999–2000 to 2017–2018. JAMA 324(12):1190–1200

    Article  PubMed  Google Scholar 

  13. Liao S, Yao W, Cheang I, Tang X, Yin T, Lu X et al (2020) Association between perfluoroalkyl acids and the prevalence of hypertension among US adults. Ecotoxicol Environ Saf 196:110589

    Article  CAS  PubMed  Google Scholar 

  14. Yao J, Hu P, Zhang D (2018) Associations between copper and zinc and risk of hypertension in US adults. Biol Trace Elem Res 186(2):346–353

    Article  CAS  PubMed  Google Scholar 

  15. Liu S, Wang X, Lu Y, Li T, Gong Z, Sheng T et al (2013) The effects of intraoperative cryoprecipitate transfusion on acute renal failure following orthotropic liver transplantation. Hepatol Int 7(3):901–909

    Article  PubMed  Google Scholar 

  16. Zachara BA, Salak A, Koterska D, Manitius J, Wasowicz W (2004) Selenium and glutathione peroxidases in blood of patients with different stages of chronic renal failure. J Trace Elem Med Biol 17(4):291–299

    Article  CAS  PubMed  Google Scholar 

  17. Lin T, Tao J, Chen Y, Zhang Y, Li F, Zhang Y, Han X et al (2022) Selenium deficiency leads to changes in renal fibrosis marker proteins and Wnt/β-catenin signaling pathway components. Biol Trace Elem Res 200(3):1127–1139

    Article  CAS  PubMed  Google Scholar 

  18. Sengul E, Gelen V, Yildirim S, Tekin S, Dag Y (2021) The effects of selenium in acrylamide-induced nephrotoxicity in rats: roles of oxidative stress, inflammation, apoptosis, and DNA damage. Biol Trace Elem Res 199(1):173–184

    Article  CAS  PubMed  Google Scholar 

  19. Zhang X, Wang Q, Zhang J, Song M, Shao B, Han Y et al (2022) The protective effect of selenium on T-2-induced nephrotoxicity is related to the inhibition of ROS-mediated apoptosis in mice kidney. Biol Trace Elem Res 200(1):206–216

    Article  CAS  PubMed  Google Scholar 

  20. Bellisola G, Guidi GC, Cinque G, Galassini S, Liu NQ, Moschini G et al (1996) Selenium status and plasma glutathione peroxidase in patients with IgA nephropathy. J Trace Elem Med Biol 10(3):189–196

    Article  CAS  PubMed  Google Scholar 

  21. McClain CJ, McClain M, Barve S, Boosalis MG (2002) Trace metals and the elderly. Clin Geriatr Med 18(4):801–818

    Article  PubMed  Google Scholar 

  22. Zachara BA (2015) Selenium and selenium-dependent antioxidants in chronic kidney disease. Adv Clin Chem 68:131–151

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

This study was supported by grants from Xinghuo Talent Program of Nanjing First Hospital, Nanjing Health Science and Technology Development Special Fund Project (Grant No. YKK21129), and the Six-one Project of Top Talents in Jiangsu Province (Grant No. LGY2020014).

Author information

Author notes

  1. Dawei Chen and Linglin Jiang contributed equally to this work.

Authors and Affiliations

  1. Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, Jiangsu, China

    Dawei Chen, Linglin Jiang & Xin Wan

  2. Department of Nephrology, Sir Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

    Mengqing Ma

Authors
  1. Dawei Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Linglin Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mengqing Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xin Wan
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

D.W. Chen, L.L. Jiang, and X. Wan contributed to the conception and design of the study. All the authors substantially contributed to the data analyses, interpretation, original manuscript, and critical revisions of this manuscript.

Corresponding author

Correspondence to Xin Wan.

Ethics declarations

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, D., Jiang, L., Ma, M. et al. Association of Blood Selenium Level with Estimated Glomerular Filtration Rate in the Aging Population: a Cross-sectional Study. Biol Trace Elem Res 201, 2258–2265 (2023). https://doi.org/10.1007/s12011-022-03351-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-022-03351-y

Keywords

Search

Navigation