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Aortic Elasticity is Impaired in Patients with Endemic Fluorosis

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Abstract

Sixty-three patients with endemic fluorosis (36 males/27 females; mean age 33.9 ± 8.6 years) and 45 age-, sex-, and body mass index-matched healthy controls (30 males/15 females; mean age 32.7 ± 8.8 years) were included in this study. Aortic stiffness indices, aortic strain (AS), aortic distensibility (AD), and aortic strain index (ASI) were calculated from the aortic diameters measured by echocardiography and blood pressure obtained by sphygmomanometry. The urine fluoride levels of fluorosis patients were significantly higher than control subjects as expected (1.9 ± 0.1 mg/l vs. 0.4 ± 0.1 mg/l, respectively; P < 0.001). AS and AD were significantly lower in fluorosis patients than in the controls (for AS 5.3 ± 3.6 vs. 8.0 ± 3.4%; P < 0.001 and for AD 0.2 ± 0.1 vs. 0.3 ± 0.1 cm2 dyn−1 10−3; P < 0.001, respectively). In contrast, signicantly higher ASI was observed in fluorosis patients than in the controls (3.4 ± 0.6 vs. 3.0 ± 0.4; P < 0.001, respectively). The results of our study demonstrate that elastic properties of ascending aorta are impaired in patients with endemic fluorosis.

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Authors and Affiliations

  1. Department of Cardiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

    Ercan Varol, Selahattin Akcay & Mehmet Ozaydin

  2. Department of Endocrinology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

    I. Hakki Ersoy & Banu Kale Koroglu

  3. Department of Geology, Faculty of Engineering, Suleyman Demirel University, Isparta, Turkey

    Simge Varol

  4. Suleyman Demirel Univesitesi Tıp Fakultesi, Sevket Demirel Kalp Merkezi, Isparta, Turkey

    Ercan Varol

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  1. Ercan Varol
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  2. Selahattin Akcay
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Correspondence to Ercan Varol.

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Varol, E., Akcay, S., Ersoy, I.H. et al. Aortic Elasticity is Impaired in Patients with Endemic Fluorosis. Biol Trace Elem Res 133, 121–127 (2010). https://doi.org/10.1007/s12011-009-8578-4

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  • DOI: https://doi.org/10.1007/s12011-009-8578-4

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