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Synthesis and Characterization of Quercetin@Ca3(PO4)2 Hybrid Nanofibers with Antibiofilm Properties and Antioxidant Activity for the Deep-frying Procedure of Sunflower Oil

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Abstract

Quercetin, the well-known abundant natural flavonoid, displays a wide range of biological and medicinal properties with antioxidant, anticancer, antimicrobial, and antibiofilm activities. However, poor aqueous solubility and low stability limit its potential prophylactic or therapeutic uses. In the present study, a novel type of quercetin-loaded Ca3(PO4)2·hybrid nanofibers (HNFs) was fabricated to overcome the mentioned restrictions. The nanostructures were instantly prepared by the incubation of a mixture containing quercetin (0.1 mg mL–1), calcium chloride (40 mM), and phosphate buffer (100 mM, pH 7.5) at 25 °C. The high-performance liquid chromatography (HPLC) results indicated a successful entrapment of quercetin into the prepared HNFs (98%). Compared to the free quercetin, the encapsulation showed 13- and fourfold increases in the prepared HNFs’ stability at 60 °C and pH 2 and 4, respectively. After a 240-min exposure to the UV light, 90% of the flavonoid loaded on the fabricated HNFs remained intact in the aqueous solution. Quercetin@Ca3(PO4)2·HNFs protected the fatty acids composition of sunflower oil from lipid peroxidation up to 55% after 70 frying cycles. The prepared HNFs (2.5 mg mL–1) disassembled biofilms formed by Staphylococcus aureus (82.5%), Bacillus subtilis (80%), Escherichia coli (66%), and Pseudomonas aeruginosa (30%). As a result, quercetin@Ca3(PO4)2·HNFs can be purposed as an antibiofilm and antioxidant to preserve sunflower oil. These promising results confirm that quercetin@Ca3(PO4)2·HNFs provide a good potential for eventual application in the food industry as an antibiofilm or antioxidant agent.

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Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.

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Funding

This work was financially supported by the Tehran University of Medical Sciences, Tehran, Iran (Grant number 1401–1-104–57255) to M.A. Faramarzi. The authors have no relevant financial or non-financial interests to disclose.

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  1. Somayeh Mojtabavi and Farnoosh Rezayaraghi should be considered joint first author.

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  1. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155−6451, Tehran, 1417614411, Iran

    Somayeh Mojtabavi, Farnoosh Rezayaraghi, Tina Adelpour, Fatemeh Kiaei & Mohammad Ali Faramarzi

  2. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155−6451, Tehran, 1417614411, Iran

    Mohammad-Reza Delnavazi

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Contributions

Somayeh Mojtabavi: conceptualization, methodology, investigation, and writing – original draft. Farnoosh Rezayaraghi: formal analysis, writing – review and editing, and conceptualization. Fatemeh Kiaei: data curation, writing – original draft preparation, visualization, and software. Tina Adelpour: methodology, investigation, and data curation. Mohammad-Reza Delnavazi: supervision, conceptualization, methodology, resources, data curation, and writing – review and editing. Mohammad Ali Faramarzi: supervision, conceptualization, methodology, resources, data curation, writing – review and editing, project administration, and funding acquisition. All authors reviewed the manuscript.

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Mojtabavi, S., Rezayaraghi, F., Adelpour, T. et al. Synthesis and Characterization of Quercetin@Ca3(PO4)2 Hybrid Nanofibers with Antibiofilm Properties and Antioxidant Activity for the Deep-frying Procedure of Sunflower Oil. Food Bioprocess Technol 16, 2184–2201 (2023). https://doi.org/10.1007/s11947-023-03053-w

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