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Sleep Disruption and Bone Health

  • Epidemiology and Pathophysiology (J Compston and M Rothman, Section Editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Review recent literature investigating the relationship between bone health and sleep/circadian disruptions (e.g., abnormal sleep duration, night shift work).

Recent Findings

Short and long sleep are associated with low bone mineral density (BMD). Recent data from observational studies identified an increased risk of fracture in women with short sleep. Studies suggest that age, sex, weight change, and concurrent circadian misalignment may modify the effects of sleep restriction on bone metabolism. Interventional studies demonstrate alterations in bone metabolism and structure in response to circadian disruption that could underlie the increased fracture risk seen with night shift work. The effects of sleep and circadian disruption during adolescence may have lifelong skeletal consequences if they adversely impact bone modeling.

Summary

Data suggest that short sleep and night shift work negatively impact bone metabolism and health. Rigorous studies of prevalent sleep and circadian disruptions are needed to determine mechanisms and develop prevention strategies to optimize lifelong skeletal health.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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The author is supported by grant numbers K23AR070275, R03AR074509, R01HL151332.

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    Christine Swanson

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Swanson, C. Sleep Disruption and Bone Health. Curr Osteoporos Rep 20, 202–212 (2022). https://doi.org/10.1007/s11914-022-00733-y

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