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Breast Arterial Calcification: A Potential Biomarker for Atherosclerotic Cardiovascular Disease Risk?

  • Women and Ischemic Heart Disease (J.M. Peña and F. Lin, Section Editors)
  • Published:
Current Atherosclerosis Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

We aimed to summarize the current evidence regarding the association between breast arterial calcification (BAC) and atherosclerotic cardiovascular disease (ASCVD) in women and discuss the potential role of BAC in the risk stratification and preventive approaches for ASCVD.

Recent Findings

BAC has emerged as a potential women-specific risk marker for ASCVD. Although BAC presents as a medial calcification of the arteries, notably different from the intimal atherosclerotic process, current evidence supports a correlation between BAC and ASCVD risk factors or subclinical and clinical ASCVD, such as coronary artery disease or stroke. As millions of women undergo mammograms each year, the potential clinical application of BAC in enhanced ASCVD risk estimation, with no additional cost or radiation, has tremendous appeal.

Summary

Although further research regarding optimal risk assessment and management in women with BAC is required, the presence of BAC should prompt healthy cardiovascular lifestyle modifications.

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Funding

This work was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF), sponsored by the Ministry of Science, ICT & Future Planning (NRF-2019R1F1A1059425).

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Authors and Affiliations

  1. Department of Radiology, New York-Presbyterian Hospital, and Weill Cornell Medicine, New York, NY, USA

    Yeonyee E. Yoon

  2. Department of Cardiology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea

    Yeonyee E. Yoon & Jung-Won Suh

  3. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

    Yeonyee E. Yoon & Jung-Won Suh

  4. Department of Radiology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea

    Bo La Yun

  5. Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea

    Bo La Yun

  6. Division of Endocrinology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyeonggi-do, Republic of Korea

    Kyoung Min Kim

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  1. Yeonyee E. Yoon
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Yoon, Y.E., Yun, B.L., Kim, K.M. et al. Breast Arterial Calcification: A Potential Biomarker for Atherosclerotic Cardiovascular Disease Risk?. Curr Atheroscler Rep 23, 21 (2021). https://doi.org/10.1007/s11883-021-00924-5

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