Abstract
Environmental air pollution is a global problem. Among the main types of air pollutants that harm human health are ozone, particulate matter (PM), nitrogen, carbon dioxide, sulfur dioxide, and carbon monoxide. These have a significant effect on human health across the world. PM can penetrate the respiratory tract, induce inflammation, and cause permanent damage. In addition, correlations have been found between PM inhalation and the development of cardiovascular diseases, various types of cancer, asthma, and lower respiratory infections. Murine models provide us with the experimental tools to understand the immunoinflammatory response to the inhalation of PM and develop preventive measures that can be extrapolated to humans. Here, we present an overview of the current understanding of the PM immune response and discuss the different experimental strategies used in research on this subject with murine models.
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We thank Cherilyn Sirois for native English editing.
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This work was supported by the Universidad Cooperativa de Colombia, and MINCIENCIAS, grant number (141580763047).
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All authors contributed to the study conception and writing—original draft preparation. Juan C. Hernandez: supervision, writing—reviewing and editing. All authors read and approved the final manuscript.
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Highlights
• Air pollution contributes to more than 4 million deaths per year.
• Particulate matter induce inflammation at the respiratory tract.
• Particulate matter can penetrate the respiratory tract and cause permanent damage.
• Murine models provide the tools for understanding the pathological response to particulate matter.
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Gomez, D.M., Tabares-Guevara, J.H., Marin-Palma, D. et al. The role of murine models in the study of the respiratory tract immune response induced by particulate matter. Air Qual Atmos Health 16, 15–23 (2023). https://doi.org/10.1007/s11869-022-01260-6
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DOI: https://doi.org/10.1007/s11869-022-01260-6