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Predictive Factors of Gastroesophageal Reflux Disease Symptoms Following Open Sleeve Gastrectomy in Brazil Using Clinical Questionnaire

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Abstract

Purpose

To evaluate predictors of symptoms of gastroesophageal reflux disease (GERD) after sleeve gastrectomy (SG) based on a clinical questionnaire.

Materials and Methods

This is a cross-sectional study. We included all patients who underwent open SG between May 2013 and March 2017 in a single institution. Patients who could not be contacted or who did not want to participate were excluded. Clinical, demographic, and pre- and postoperative data were collected on medical records. Patients were contacted via telephone and inquired about GERD symptoms postoperatively. Symptoms were quantified using the GERD Questionnaire (GERDq). Patients were divided into three study groups according to GERDq score: asymptomatic (GERDq = 0), mildly symptomatic (GERDq ≤ 8), and severely symptomatic (GERDq > 8). Univariate analysis was performed using ANOVA, Kruskal-Wallis, Dunn, and chi-square tests. A logistic regression model was built for adjusted analysis of the data.

Results

One hundred eighty-nine patients were included. Mean age was 39.7 ± 10.71 years and 45.5% were female. Postoperative median follow-up period was 4.55 years (interquartile range 5.34–3.76). Mean GERDq score was 7.62 ± 10.17. Sixty-four patients were asymptomatic, 63 were mildly symptomatic, and 62 were severely symptomatic. The group of severely symptomatic patients showed a statistically lower preoperative weight when compared to the other groups (p = 0.049), but this association was not observed when analyzing preoperative BMI (p = 0.427). The other variables were not associated with postoperative GERD symptoms, both in univariate and adjusted analysis.

Conclusion

No variables were statistically and clinically predictive of GERD occurrence or severity after SG. The pathophysiology of GERD is complex and further studies are needed to elucidate this condition.

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Authors and Affiliations

  1. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Camila R. Guetter

  2. Department of Gastrointestinal Surgery, Hospital Santa Casa de Curitiba, Curitiba, Paraná, Brazil

    Victor K. Ivano, Alcides J. Branco Filho & André T. Nassif

  3. Pontifical Catholic University of Paraná School of Medicine, Curitiba, Paraná, Brazil

    Roberta V. Pintan & Alice P. Cavassola

  4. Positivo University School of Medicine, Curitiba, Paraná, Brazil

    André T. Nassif

Authors
  1. Camila R. Guetter
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  2. Victor K. Ivano
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  3. Roberta V. Pintan
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  4. Alice P. Cavassola
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  5. Alcides J. Branco Filho
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  6. André T. Nassif
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Corresponding author

Correspondence to André T. Nassif.

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Ethical Statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Guetter, C.R., Ivano, V.K., Pintan, R.V. et al. Predictive Factors of Gastroesophageal Reflux Disease Symptoms Following Open Sleeve Gastrectomy in Brazil Using Clinical Questionnaire. OBES SURG 31, 3090–3096 (2021). https://doi.org/10.1007/s11695-021-05333-w

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  • DOI: https://doi.org/10.1007/s11695-021-05333-w

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